Paracetamol recall: a natural experiment influencing analgesic poisoning.

The Medical Journal of Australia
Corrine R BalitIan Whyte

Abstract

To determine whether the occurrence of paracetamol and non-paracetamol analgesic deliberate self-poisoning (DSP) and accidental paediatric poisoning was affected by two periods of recall of paracetamol products. Retrospective, observational audit of proportions of poisonings with tablet and capsule formulations of paracetamol, ibuprofen and aspirin products during two recall periods compared with the number of poisonings during the same periods of the previous three years. A national poisons information centre and a regional toxicology service. Rates of DSP and accidental paediatric poisoning with paracetamol, ibuprofen and aspirin. During the two recall periods, there was a significant increase in ibuprofen DSP calls to the poisons information centre (RR, 1.86; 95% Cl, 1.41-2.44; P = 0.001). There was no significant change in paracetamol or aspirin DSP calls over the two recall periods. However, there was a non-significant reduction in DSP calls with paracetamol in the first recall period alone (P = 0.057). There was a significant increase in the proportion of aspirin DSP presentations for the toxicology service (RR, 3.33; 95% CI, 0.97-11.4; P = 0.043), but no significant changes in paracetamol and ibuprofen DSP presentations....Continue Reading

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Citations

Nov 17, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Joe-Anthony RotellaShaun Greene
Jul 30, 2002·Journal of Toxicology. Clinical Toxicology·Ian M WhyteAndrew H Dawson
Jan 16, 2003·The Medical Journal of Australia·Stephen R KiselyNeil J Preston
Jul 6, 2010·Journal of Paediatrics and Child Health·Geoffrey K IsbisterHenry A Kilham
Oct 6, 2010·Journal of Clinical Nursing·Misel TrajanovskaLinda Johnston

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