Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis.

The Cochrane Database of Systematic Reviews
T Wienecke, Peter C Gøtzsche

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually preferred for simple analgesics such as paracetamol for rheumatoid arthritis. It is not clear, however, whether the trade-offs between benefits and harms of NSAIDs are preferable to those of paracetamol (paracetamol is also called acetaminophen). To compare the benefits and harms of paracetamol with NSAIDs in patients with rheumatoid arthritis. Medline Silverplatter, Embase databases were searched up until Sept 2002. Reference lists of identified articles were also searched. Randomised double-blind studies comparing paracetamol with an NSAID. Decisions on inclusion of trials and data extraction were performed by the two authors independently. Four cross-over studies, published between 1968 and 1982, involving 121 patients, and four different NSAIDs were included. The generation of the allocation sequence and the use of methods to conceal the allocation were not described in any of the studies. The studies were double-blind but it was not clear whether the blinding was effective. Methods for collecting adverse effects were not described. The NSAIDs were preferred more often than paracetamol by the patients or the investigator. In the largest trial, 20 out of 54 patients (...Continue Reading

References

Jan 1, 1985·Annals of the Rheumatic Diseases·T Gibson, B Clark
Sep 1, 1959·Annals of the Rheumatic Diseases·J HAJNALA J POPERT
Feb 20, 2004·The Cochrane Database of Systematic Reviews·T Wienecke, P C Gøtzsche
May 27, 2004·JAMA : the Journal of the American Medical Association·An-Wen ChanDouglas G Altman
May 23, 2007·International Journal of Epidemiology·J PildalP C Gøtzsche

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Citations

Sep 17, 2014·The Cochrane Database of Systematic Reviews·Caroline M P G van DurmeRobert B M Landewé
May 28, 2014·Nature Reviews. Rheumatology·David A Walsh, Daniel F McWilliams
Jun 7, 2018·Pain and Therapy·Fabiola AtzeniPiercarlo Sarzi-Puttini
Oct 23, 2012·British Journal of Pharmacology·Bruno Georg Oertel, Jörn Lötsch
Feb 20, 2004·The Cochrane Database of Systematic Reviews·T Wienecke, P C Gøtzsche
Jun 7, 2020·Zeitschrift für Rheumatologie·M SchneiderC Specker
Dec 10, 2021·The Cochrane Database of Systematic Reviews·Caroline Mpg van DurmeRachelle Buchbinder

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