Paracetamol versus placebo for knee and hip osteoarthritis.

The Cochrane Database of Systematic Reviews
Amanda O LeopoldinoManuela L Ferreira

Abstract

Paracetamol (acetaminophen) is vastly recommended as the first-line analgesic for osteoarthritis of the hip or knee. However, there has been controversy about this recommendation given recent studies have revealed small effects of paracetamol when compared with placebo. Nonetheless, past studies have not systematically reviewed and appraised the literature to investigate the effects of this drug on specific osteoarthritis sites, that is, hip or knee, or on the dose used. To assess the benefits and harms of paracetamol compared with placebo in the treatment of osteoarthritis of the hip or knee. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, AMED, CINAHL, Web of Science, LILACS, and International Pharmaceutical Abstracts to 3 October 2017, and ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP) portal on 20 October 2017. We included randomised controlled trials comparing paracetamol with placebo in adults with osteoarthritis of the hip or knee. Major outcomes were pain, function, quality of life, adverse events and withdrawals due to adverse events, serious adverse events, and abnormal liver function tests. Two review authors used standard ...Continue Reading

References

Jan 1, 1983·Archives of Orthopaedic and Trauma Surgery·J IsolauriP Rokkanen
Dec 26, 2001·The New England Journal of Medicine·L J Crofford
Apr 24, 2003·Rheumatology·B M Rothschild
Dec 3, 2003·Annals of the Rheumatic Diseases·K M JordanUNKNOWN Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT
Mar 24, 2004·Inflammopharmacology·Garry G Graham, Kieran F Scott
Jul 14, 2004·Annals of the Rheumatic Diseases·C Miceli-RichardM Dougados
Oct 9, 2004·Annals of the Rheumatic Diseases·W ZhangUNKNOWN EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
Jan 27, 2006·The Cochrane Database of Systematic Reviews·T E TowheedG Wells
Mar 15, 2006·Advanced Drug Delivery Reviews·Joseph A Buckwalter, James A Martin
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Peter JüniPaul Dieppe
Apr 18, 2007·Annals of Internal Medicine·Stephan ReichenbachPeter Jüni
Jul 27, 2007·JAMA : the Journal of the American Medical Association·Peter C GøtzscheBritta Tendal
Sep 22, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Burkhard HinzKay Brune
Mar 25, 2008·Current Medical Research and Opinion·Jeff R ScheinJohn D Freedman
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Oct 16, 2013·Arthritis Care & Research·Caroline A BrandKim Bennell
Dec 3, 2013·The Journal of Rheumatology·Elizabeth A T GhogomuUNKNOWN Editorial Board of the Cochrane Musculoskeletal Group
Mar 26, 2014·Annals of the Rheumatic Diseases·Damian HoyRachelle Buchbinder
Mar 4, 2015·Annals of the Rheumatic Diseases·Emmert RobertsPhilip G Conaghan

❮ Previous
Next ❯

Citations

Feb 1, 2020·Expert Opinion on Pharmacotherapy·Sunny TrivediC Thomas Vangsness
Jan 2, 2020·BMJ : British Medical Journal·Bruno T SaragiottoChris G Maher
Jun 17, 2019·BMJ Evidence-based Medicine·Igho J Onakpoya
Aug 17, 2020·The Cochrane Database of Systematic Reviews·Peter JonesStuart R Dalziel
May 4, 2021·Frontiers in Pharmacology·Xiaoyan CaiChanghai Ding
Feb 12, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Ben HudsonLes Toop
Jun 6, 2021·BMC Musculoskeletal Disorders·Swan Sim YeapMaw Pin Tan
Aug 8, 2021·Journal of Clinical Medicine·Ulderico FreoEnzo Nisoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
Bruno T SaragiottoChristopher G Maher
The Cochrane Database of Systematic Reviews
Jasvinder A SinghLara J Maxwell
The Cochrane Database of Systematic Reviews
Livia PuljakPeter Tugwell
© 2022 Meta ULC. All rights reserved