Paracoccidioides brasiliensis habitat: far beyond armadillo burrows?

Memórias do Instituto Oswaldo Cruz
Priscila Marques de MacedoBodo Wanke

Abstract

Paracoccidioides spp. isolation from environmental samples is rare and hardly reproducible. Molecular techniques have facilitated the fungal detection. However, it can be still difficult. Some strategies to enhance the capacity of DNA detection have been adopted, including the analysis of soil samples belonging to the habitat of animals from which Paracoccidioides spp. have already been isolated, notably armadillo burrows. To date, the detection of Paracoccidioides spp. has not yet been reported from outbreak hotspots. Clusters and outbreaks of acute paracoccidioidomycosis (PCM), usually a more severe clinical form, have currently occurred in urban areas being associated to climate changes, deforestation, and great constructions. These occurrences potentially signalise the fungus' environmental niche, a riddle not yet solved. The authors performed an environmental investigation in a deeply disturbed area, after a highway construction in Rio de Janeiro, Brazil, where a recent outbreak of acute PCM occurred. Specific DNA sequences of Paracoccidioides brasiliensis were detected in shallow soil samples around the highway, reinforcing the association between the road construction and this PCM outbreak.

References

Jul 13, 2000·Medical Mycology·M FrancoC da Silva Lacaz
Jul 12, 2001·Medical Mycology·A RestrepoE Castañeda
Jan 21, 2006·Medical Mycology·Raquel Cordeiro TheodoroEduardo Bagagli
Apr 3, 2010·PLoS Neglected Tropical Diseases·Ligia Vizeu BarrozoRinaldo Poncio Mendes
Jul 27, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Aparecida Shikanai-YasudaRoberto Martinez
Oct 20, 2017·Emerging Infectious Diseases·Antonio C Francesconi do ValleBodo Wanke
Jan 3, 2019·Current Microbiology·Josiara Furtado MendesMelissa Orzechowski Xavier

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Datasets Mentioned

BETA
MT726207
MT726209

Methods Mentioned

BETA
PCR

Software Mentioned

BLAST

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