PMID: 12775434May 31, 2003Paper

Paracorporeal artificial lung: perioperative management for survival study in sheep

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
S D LickJ B Zwischenberger

Abstract

An artificial lung may offer a bridge to recovery or transplant. Utilizing our recently developed paracorporeal artificial lung (PAL) in survival studies in sheep, we critically review our perioperative/anesthetic protocol. Adult Suffolk ewes (n = 15) underwent general anesthesia induced by ketamine (7-15 mg/kg, im) and isoflurane by mask, then intubated and maintained by 4.0-5.0% isoflurane titrated to mean arterial pressure (MAP) 70-110 mm Hg. After a latissimus-sparing thoracotomy and systemic heparinization (200 IU/kg), arterial grafts were anastomosed to the proximal and distal main pulmonary artery in an end-of-graft to side-of-artery fashion. A snare was passed around the pulmonary artery between anastomoses. When the snare was tightened, full pulmonary blood flow was diverted through the cannulae and immediately through the PAL. Perioperative crystalloids included a 500-mL prime, lactated Ringer's (LR) titrated to CVP 5-7 mm Hg, and a heparin infusion (activated clotting time [ACT] 250-300 s). Buprenorphine (0.3 mg im tid) controlled postoperative pain. Hemodynamic parameters, arterial blood gases (ABGs), and ACTs were measured every 6 h. Thirteen of 15 sheep survived the operation and were extubated in less than 20 min...Continue Reading

Citations

Jul 12, 2011·Critical Care Clinics·James E LynchJoseph B Zwischenberger
Oct 24, 2007·The Annals of Thoracic Surgery·Dongfang WangJoseph B Zwischenberger
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Frank C Schmalstieg, Joseph B Zwischenberger
Nov 27, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangJoseph B Zwischenberger

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