Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis

EBioMedicine
Stacy K ThomasGregory L Beatty

Abstract

Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features support the metastatic ability of cancer cells, permissive microenvironments within the primary organ and at sites of distant metastasis may be rate-limiting. Identification of cancer cell-extrinsic factors that regulate formation of these environments lend new therapeutic targets for intervening on the metastatic cascade. In addition, the bipolar, yet fundamental, role of the immune system in the metastatic process presents therapeutic opportunities. Herein, we review the current knowledge of the metastatic cascade in PDAC, and propose that genomically stable determinants of metastasis (e.g. the pro-metastatic niche and immune system) are actionable targets for preventing, containing, and treating metastasis in PDAC.

Citations

Aug 28, 2020·The Journal of International Medical Research·Adewale Oluwaseun FadakaMervin Meyer
Sep 23, 2020·Nature Reviews. Cancer·Andreas Möller, Richard J Lobb
Feb 26, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Ewa WronaMaciej Borowiec
Apr 26, 2021·Pharmacology & Therapeutics·Sian ChenXian Shen
May 25, 2021·World Journal of Gastroenterology : WJG·Faran PolaniKian-Huat Lim
Oct 14, 2021·Pancreas·Arnav BhattacharyaSitaram Harihar

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Datasets Mentioned

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GM-CSF

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surgical resection

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