Paracrine control of glucagon release by somatostatin (Review)

International Journal of Molecular Medicine
Willy J Malaisse

Abstract

Emphasis was recently placed on the modulation of glucagon secretion attributable to a paracrine effect of somatostatin. This review draws attention to prior findings related to such a view. The effects of nutrient secretagogues upon insulin, somatostatin and glucagon release by the perfused pancreas are first considered. Three examples of paradoxical secretory responses of insulin- and glucagon-producing cells are then given. Further experiments dealing with the possible role of somatostatin upon glucagon release and the relevance of pancreatic compartmentation are also presented. It is concluded that these prior findings provide, within limits, support to the postulated paracrine role of somatostatin in the control of glucagon secretion.

References

Nov 15, 1979·The Biochemical Journal·J C HuttonW J Malaisse
Aug 1, 1992·Metabolism: Clinical and Experimental·W J MalaisseA Sener
Jan 1, 1990·Metabolism: Clinical and Experimental·G MarynissenW J Malaisse
Dec 1, 1987·Experientia·V Leclercq-MeyerW J Malaisse
Jun 1, 1981·Endocrinology·V Leclercq-MeyerW J Malaisse
Feb 1, 1993·The Journal of Clinical Investigation·W J MalaisseA Sener
Mar 15, 1996·Archives of Biochemistry and Biophysics·H JijakliW J Malaisse
Apr 19, 1996·Molecular and Cellular Endocrinology·D Mercan, W J Malaisse
Dec 24, 1996·Biochemical and Biophysical Research Communications·V Leclercq-MeyerW J Malaisse
Jul 10, 1998·Endocrine·V Leclercq-MeyerW J Malaisse

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Citations

Jul 22, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·John R RichardsGuillermo Burillo-Putze

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