Paracrine coronary endothelial modulation of diastolic left ventricular function in man: implications for diastolic heart failure

Journal of Cardiac Failure
W J Paulus

Abstract

Coordinated release of relaxing and contracting factors from the endothelium modulates arterial distensibility. Recently, a similar release of the same and other factors from the coronary endothelium was shown to modulate myocardial performance in humans. This paracrine modulation of left ventricular (LV) performance by substances released from the coronary endothelium mainly affects diastolic LV function. This was evident from the reduction in end-systolic LV pressure, the earlier onset of LV relaxation and the increased LV diastolic distensibility observed in normal subjects during bi-coronary infusion of substance P. In experimental preparations, substance P elicited similar effects on diastolic LV function, which were attributed to a paracrine myocardial action of nitric oxide (NO) because they were absent after addition of hemoglobin. In normal subjects, the myocardial effects of NO were investigated during bi-coronary infusion of the NO-donor sodium nitroprusside and resembled the effects observed during bi-coronary infusion of substance P. This paracrine control of diastolic LV function by the coronary endothelium is influenced by substrate availability and by many neurohumoral substances, whose plasma levels are raised ...Continue Reading

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Citations

Oct 23, 1997·Journal of Cardiac Failure·D L Brutsaert, S U Sys
Jun 23, 2000·Journal of the American Veterinary Medical Association·J R Turk
Sep 15, 2000·Cardiology Clinics·E L Yellin, J S Meisner
Oct 9, 2012·Journal of the American College of Cardiology·Carolyn S P Lam, Dirk L Brutsaert
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R GyurkoP L Huang

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