Paracrine effects of cell transplantation: strategies to augment the efficacy of cell therapies

Seminars in Thoracic and Cardiovascular Surgery
Andrew S Cheng, Terrence M Yau

Abstract

Within the last few years, it has become evident that the beneficial effect of cell transplantation on ventricular function and myocardial perfusion is in large part mediated through paracrine effects on the host myocardium. Studies in which medium conditioned by cultured cells, usually mesenchymal stem cells, were injected into infarcted animal hearts have provided definitive evidence of this mechanism of action. Paracrine effects of the donor cells include but are not limited to angiogenesis, mobilization of both circulating and bone-marrow-derived stem cells, activation of cardiac-resident stem cells (CRSCs), and stabilization of the extracellular matrix (ECM). These paracrine effects can be augmented by transplantation of cells modified to express therapeutically useful transgenes, or by preconditioning through hypoxic or pharmacologic means. Strategies to enhance the paracrine effects of cell transplantation may thus be employed in the next generation of cell therapies, with greater functional benefit.

References

Sep 1, 1996·The Annals of Thoracic Surgery·R K LiJ Ivanov
Apr 13, 1999·Journal of Molecular and Cellular Cardiology·R K LiD A Mickle
Jul 29, 1999·The Journal of Surgical Research·B Z AtkinsD A Taylor
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·T SakaiT M Yau
Dec 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·R K LiT M Yau
Jan 5, 2000·The Annals of Thoracic Surgery·T SakaiT M Yau
Mar 28, 2001·The Annals of Thoracic Surgery·B PouzetP Menasché
Apr 5, 2001·Nature·D OrlicP Anversa
Nov 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·E J KimT M Yau
May 22, 2002·Circulation·Wilhelm RoellBernd K Fleischmann
Jun 14, 2002·The Journal of Thoracic and Cardiovascular Surgery·Shinji TomitaRen-Ke Li
Aug 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekPiero Anversa
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Apr 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryo MatsumotoJunichi Yoshikawa
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Axel LinkePiero Anversa
Sep 15, 2005·Circulation·Terrence M YauRen-Ke Li
Oct 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Xiaohua XuGuanghui Cui
Oct 26, 2005·The Annals of Thoracic Surgery·Terrence M YauRen-Ke Li
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Shafie FazelRen-Ke Li
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Paul W M FedakRen-Ke Li

❮ Previous
Next ❯

Citations

Aug 6, 2013·Translational Stroke Research·Shan Ping YuLing Wei
Nov 10, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masaho OkadaJohnny Huard
Nov 11, 2010·Human Gene Therapy·Yeong-Hoon ChoiChristof Stamm
Jan 23, 2010·Stem Cells and Development·Premal TrivediG Ian Gallicano
May 4, 2011·Stem Cells and Development·Sveva BolliniPaolo De Coppi
Dec 31, 2011·Stem Cell Research & Therapy·Rubens Camargo Siqueira
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Rubens Camargo Siqueira
Jan 30, 2014·Scandinavian Cardiovascular Journal : SCJ·Jun FangLingzhen Wu
Dec 22, 2015·Current Urology Reports·Aram KimMyung-Soo Choo
Aug 30, 2011·The Veterinary Clinics of North America. Equine Practice·John F Peroni, Dori L Borjesson
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Milena Botelho Pereira Soares, Ricardo Ribeiro dos Santos
Mar 23, 2010·Asian Cardiovascular & Thoracic Annals·Olivier SchusslerMarc Ruel
Jan 16, 2019·Journal of Tissue Engineering and Regenerative Medicine·Tarini Nawamalie Abeysinghe GunawardenaNoor Hayaty Abu Kasim
Dec 21, 2011·Journal of Biomaterials Science. Polymer Edition·Hidefumi IshikawaYasuhiko Tabata
Aug 28, 2019·Therapeutic Advances in Urology·Elliot B LanderJackie R See
Feb 11, 2020·Journal of Cellular Physiology·Diogo S PintoCláudia L da Silva
Jan 9, 2016·In Vitro Cellular & Developmental Biology. Animal· JasminRosalia Mendez-Otero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Massimiliano GnecchiVictor J Dzau
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Xabier L ArangurenAernout Luttun
Regenerative Medicine
Edward A Phelps, Andres J Garcia
© 2022 Meta ULC. All rights reserved