Paracrine Mechanisms Involved in Mesenchymal Stem Cell Differentiation into Cardiomyocytes

Current Stem Cell Research & Therapy
Maryam FarzanehSeyed E Khoshnam

Abstract

Cardiovascular Disease (CVD) is one of the world-wide healthcare problem that involves the heart or blood vessels. CVD includes myocardial infarction and coronary artery diseases (CAD). Dysfunctional myocardial cells are leading causes of low cardiac output or ventricular dysfunction after cardiac arrest and may contribute to the progression of CVD which could not generate new cardiomyocytes in human adult heart. The mesenchymal stem cells (MSCs) which are present in adult marrow can self-renew and have the capacity of differentiation into multiple types of cells including cardiomyocytes. Recent biochemical analyses greatly revealed that several regulators of MSCs, such as HGF, PDGF, Wnt, and Notch-1 signaling pathways have been shown to be involved in the proliferation and differentiation into cardiomyocytes. Preclinical studies are paving the way for further applications of MSCs in the repair of myocardial infarction. In this study, we discuss and summarize the paracrine mechanisms involved in MSCs differentiation into cardiomyocytes.

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Citations

Oct 28, 2019·Current Stem Cell Research & Therapy·Mehdi ForouzeshSeyed Esmaeil Khoshnam
Mar 18, 2020·Current Stem Cell Research & Therapy·Masoumeh AlishahiSeyed E Khoshnam
Sep 26, 2020·Translational Stroke Research·Meng LuSeyed Esmaeil Khoshnam
Jul 13, 2019·Journal of Biological Engineering·Anh H NguyenHung Cao
Feb 1, 2019·Terapevticheskiĭ arkhiv·K V DergilevЕ V Parfyonova
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Immacolata BelvisoClotilde Castaldo
Oct 8, 2020·International Journal of Molecular Sciences·Kamila RaziyevaArman Saparov
Mar 2, 2021·Experimental Biology and Medicine·Carmen WolkeUwe Lendeckel
May 11, 2021·Frontiers in Cell and Developmental Biology·Chuanbin LiuFeng Cao

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