Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration

Trends in Cell Biology
Arnau HerveraSimone Di Giovanni

Abstract

Adult postmitotic mammalian cells, including neurons and cardiomyocytes, have a limited capacity to regenerate after injury. Therefore, an understanding of the molecular mechanisms underlying their regenerative ability is critical to advance tissue repair therapies. Recent studies highlight how redox signalling via paracrine cell-to-cell communication may act as a central mechanism coupling tissue injury with regeneration. Post-injury redox paracrine signalling can act by diffusion to nearby cells, through mitochondria or within extracellular vesicles, affecting specific intracellular targets such as kinases, phosphatases, and transcription factors, which in turn trigger a regenerative response. Here, we review redox paracrine signalling mechanisms in postmitotic tissue regeneration and discuss current challenges and future directions.

Citations

Jul 30, 2020·Cells·Michela Rigoni, Samuele Negro
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Jialiang LiangPing Zhu
Oct 6, 2020·Frontiers in Physiology·Raquel Figuinha Videira, Paula A da Costa Martins
Jan 29, 2021·Antioxidants·Steen Vang PetersenFrederik Vilhardt
Dec 29, 2020·Progress in Neurobiology·Francina Mesquida-VenyArnau Hervera
Dec 5, 2021·Antioxidants & Redox Signaling·Stephanie A EidEva L Feldman

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