PMID: 9556126Apr 29, 1998Paper

Paracrine regulation of cardiac myocytes in normal and septic heart

Journal of Critical Care
S CordaDidier Payen

Abstract

A paracrine pathway for the regulation of cardiac contractile function by nonmuscle cells is documented in the heart. Coronary and endocardial endothelium release several diffusible agents, such as prostaglandins, endothelin-1, and nitric oxide, with an action on cardiac myocyte function. Cardiac diseases involving an immune or inflammatory mechanism, such as endotoxic shock, are now seen as conditions in which cross-talk between different cell types in the heart is clearly implicated. The potential biological relevance of inducible nitric oxide synthase in the myocardium, and the subsequent production of nitric oxide has been proposed as a mechanism of the cardiac depression observed in septic shock. In addition to cardiac myocytes, activated microvascular endothelial cells and cardiac endothelial cells may contribute to nitric oxide generation and, ultimately, to the depression of myocardial contractile activity during sepsis. This article reviews the local intercellular communication between cardiac myocytes and endothelial cells in the normal heart and discusses some of the mechanisms potentially claimed to depress heart function in sepsis.

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Citations

Apr 21, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christophe RabuelAlexandre Mebazaa
Aug 8, 2009·The New Phytologist·Verónica S Di StilioCaitlin F Connelly
Sep 27, 2007·Genetical Research·Lisete Galego, Jorge Almeida
Aug 16, 2001·Journal of Cardiothoracic and Vascular Anesthesia·A KumarJ E Parrillo

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