PMID: 9182684Jun 16, 1997Paper

Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway

The Journal of Experimental Medicine
R van der VoortS T Pals

Abstract

T cell-dependent humoral immune responses are initiated by the activation of naive B cells in the T cell areas of the secondary lymphoid tissues. This primary B cell activation leads to migration of germinal center (GC) cell precursors into B cell follicles where they engage follicular dendritic cells (FDC) and T cells, and differentiate into memory B cells or plasma cells. Both B cell migration and interaction with FDC critically depend on integrin-mediated adhesion. To date, the physiological regulators of this adhesion were unkown. In the present report, we have identified the c-met-encoded receptor tyrosine kinase and its ligand, the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF), as a novel paracrine signaling pathway regulating B cell adhesion. We observed that c-Met is predominantly expressed on CD38(+)CD77(+) tonsillar B cells localized in the dark zone of the GC (centroblasts). On tonsil B cells, ligation of CD40 by CD40-ligand, induces a transient strong upregulation of expression of the c-Met tyrosine kinase. Stimulation of c-Met with HGF/SF leads to receptor phosphorylation and, in addition, to enhanced integrin-mediated adhesion of B cells to both VCAM-1 and fibronectin. Importantly, th...Continue Reading

References

Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Mar 1, 1991·The Journal of Experimental Medicine·K MiyakeP W Kincade
Mar 8, 1991·Cell·E Ruoslahti, Y Yamaguchi
Nov 1, 1990·The Journal of Cell Biology·K M WeidnerW Birchmeier
Oct 1, 1990·Immunological Reviews·J G TewA K Szakal
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M ParkG Vande Woude
Sep 1, 1987·European Journal of Immunology·G D KeizerJ E De Vries
Jan 1, 1994·Annual Review of Immunology·J BanchereauS Saeland
May 5, 1995·Science·C ArpinY J Liu
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D S GrantE M Rosen
Dec 1, 1994·Current Opinion in Immunology·T J Schall, K B Bacon
Dec 1, 1994·Protein Science : a Publication of the Protein Society·L E DonateT L Blundell
Jul 1, 1994·The Journal of Experimental Medicine·V PascualJ D Capra
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Jan 1, 1994·Annual Review of Immunology·P M Murphy
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G J ThorbeckeV K Tsiagbe
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S RongG F Vande Woude
Dec 1, 1993·Journal of Leukocyte Biology·D J KelvinJ M Wang
Jul 1, 1993·The Journal of Experimental Medicine·M G McHeyzer-WilliamsG J Nossal
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S GiordanoP M Comoglio
Jul 15, 1993·Biochemical and Biophysical Research Communications·K MizunoT Nakamura
May 1, 1993·European Journal of Immunology·D L HardieI C MacLennan

❮ Previous
Next ❯

Citations

Apr 16, 2010·Basic Research in Cardiology·Rosalinda MadonnaRoberto Bolli
Feb 24, 2006·Journal of Biomedical Science·Po-Chao ChanHong-Chen Chen
Nov 14, 2000·The American Journal of Pathology·V J WielengaS T Pals
Oct 16, 2002·Biochemical and Biophysical Research Communications·Taher E I TaherSteven T Pals
Aug 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SkibinskiK James
Aug 7, 2002·Seminars in Immunology·Kirsten van Nierop, Cornelis de Groot
Oct 13, 2000·Progress in Retinal and Eye Research·I GriersonS Hagan
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·G GaidanoA Carbone
Oct 17, 2007·Immunology and Cell Biology·Di YuCarola G Vinuesa
Oct 14, 2006·Leukemia·R J BendeC J M van Noesel
Mar 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mahdia BenkhouchaPatrice H Lalive
Nov 12, 2003·The Journal of Experimental Medicine·Marcel SpaargarenSteven T Pals
Jan 17, 2008·Blood·Karissa D McCall-CulbreathMary M Zutter
Jun 14, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Eiichi Gohda
Jan 5, 2014·Pharmacology & Therapeutics·Christiane R Maroun, Tracey Rowlands
Nov 21, 1998·Cell Adhesion and Communication·S T PalsR M Keehnen
Feb 23, 1999·The American Journal of Pathology·V J WielengaS T Pals
Jun 6, 2009·Microbial Pathogenesis·Denise S McElroySarah E F D'Orazio
Dec 23, 2008·Cancer Letters·Christine M Stellrecht, Varsha Gandhi
Feb 16, 1999·The Journal of Investigative Dermatology·G PiccininiM Introna
Apr 16, 2003·European Journal of Haematology·Liang-Tsai HsiaoPo-Min Chen
Jul 13, 2005·European Journal of Haematology. Supplementum·Ralf KüppersMartin-Leo Hansmann
Apr 22, 2015·Pharmacogenomics·Cristina Pérez-RamírezMiguel Ángel Calleja-Hernández
May 10, 2017·Journal of Immunology Research·Vanloan NguyenJames W Larrick
Jun 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shahab UddinKhawla S Al-Kuraya
Jun 4, 2015·PloS One·Marta Tejera-AlhambraSilvia Sánchez-Ramón
Jan 16, 2019·International Journal of Molecular Sciences·Paolo GiannoniDaniela de Totero
May 28, 2010·Journal of Cellular Biochemistry·Angelina FeliciDonald P Bottaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.