Feb 14, 2017

Paracrine regulation of melanocyte genomic stability: a focus on nucleotide excision repair

Pigment Cell & Melanoma Research
Stuart G JarrettJohn A D'Orazio

Abstract

UV radiation is a major environmental risk factor for the development of melanoma by causing DNA damage and mutations. Resistance to UV damage is largely determined by the capacity of melanocytes to respond to UV injury by repairing mutagenic photolesions. The nucleotide excision repair (NER) pathway is the major mechanism by which cells correct UV photodamage. This multistep process involves the basic steps of damage recognition, isolation, localized strand unwinding, assembly of a repair complex, excision of the damage-containing strand 3' and 5' to the photolesion, synthesis of a sequence-appropriate replacement strand, and finally ligation to restore continuity of genomic DNA. In melanocytes, the efficiency of NER is regulated by several hormonal pathways including the melanocortin and endothelin signaling pathways. Elucidating molecular mechanisms by which melanocyte DNA repair is regulated offers the possibility of developing novel melanoma-preventive strategies to reduce UV mutagenesis, especially in UV-sensitive melanoma-prone individuals.

  • References89
  • Citations5

References

Mentioned in this Paper

Biochemical Pathway
Melanocyte
Strategy
DNA Repair
Isolation Aspects
Error-prone Translesion Synthesis
Genomic Stability
Base Excision Repair
Hormone-mediated Signaling Pathway
Paracrine Communication

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