Paradoxical coronary microcirculatory constriction during ischemia: a synergic function for nitric oxide and endothelin

American Journal of Physiology. Heart and Circulatory Physiology
Claudia KusmicG Sambuceti

Abstract

A paradoxical microcirculatory constriction has been observed in hearts of patients with ischemia, secondary to coronary stenosis. Here, using the isolated mouse heart (Langendorff), we examined the mechanism of this response, assuming involvement of nitric oxide (NO) and endothelin-1 (ET-1) systems. Perfusion pressure was maintained at 65 mmHg for 70 min (protocol 1), or it was reduced to 30 mmHg over two intervals, between the 20- and 40-min marks (protocol 2) or from the 20-min mark onward (protocol 3). In protocol 1, coronary resistance (CR) remained steady in untreated heart, whereas it progressively increased during treatment with the NO synthesis inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME) (2.7-fold) or the ET(A) antagonist BQ-610 (2.8 fold). The ET(B) antagonist BQ-788 had instead no effect by itself but curtailed vasoconstriction to BQ-610. In protocol 2, hypotension raised CR by 2.2-fold. This response was blunted by reactive oxygen species (ROS) scavengers (mannitol and superoxide dismutase plus catalase) and was converted into vasodilation by l-NAME, BQ-610, or BQ-788. Restoration of normal pressure was followed by vasodilation and vasoconstriction, respectively, in untreated and treated preparations. In p...Continue Reading

References

Sep 1, 1977·The American Journal of Cardiology·R A GuytonL L Michaelis
May 1, 1990·Journal of Cardiovascular Pharmacology·A R BaydounB Woodward
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Jan 1, 1987·Progress in Cardiovascular Diseases·W P Dole
Dec 1, 1980·Circulation Research·R M Berne
Oct 1, 1982·Circulation Research·M W Gorman, H V Sparks
Mar 1, 1995·Basic Research in Cardiology·D V DeFily, W M Chilian
Feb 26, 1996·FEBS Letters·E R FrearsP G Winyard
Feb 19, 1998·Circulation Research·A GödeckeJ Schrader
Jan 27, 1999·Pulmonary Pharmacology & Therapeutics·B Battistini, P Dussault
Nov 13, 1999·Circulation Research·C Fernandez-PatronS T Davidge
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G SambucetiA L'Abbate
Dec 18, 2001·Cardiovascular Research·Wenjie WangRichard Schulz
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Song-Jung KimStephen F Vatner
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Takashi SaitoMamoru Miura
Nov 5, 2003·Circulation·Stuart Rich, Vallerie V McLaughlin
Apr 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Gianmario SambucetiAntonio L'Abbate

❮ Previous
Next ❯

Citations

Jun 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew L EdinDarryl C Zeldin
Aug 30, 2011·The American Journal of Cardiology·Alberto Ranieri De CaterinaFilippo Crea
Aug 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mary G Leonard, Anil Gulati
Apr 4, 2007·Annals of the New York Academy of Sciences·George KoliakosMartha Kaloyianni
Jan 29, 2010·Journal of Cellular Biochemistry·Claudia KusmicNader G Abraham
Feb 23, 2017·The Journal of Pharmacology and Experimental Therapeutics·Magali VercauterenMartine Clozel
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Antonio L'AbbateNader G Abraham
Mar 9, 2019·Free Radical Biology & Medicine·Hong YuRonald J Korthuis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Adelino F Leite-Moreira, Carmen Brás-Silva
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
S R MagerP H J Riegman
American Journal of Physiology. Renal Physiology
Susan K Fellner, William J Arendshorst
© 2022 Meta ULC. All rights reserved