Paradoxical Decision-Making: A Framework for Understanding Cognition in Parkinson's Disease

Trends in Neurosciences
Alessandra PeruginiMichele A Basso

Abstract

People with Parkinson's disease (PD) show impaired decision-making when sensory and memory information must be combined. This recently identified impairment results from an inability to accumulate the proper amount of information needed to make a decision and appears to be independent of dopamine tone and reinforcement learning mechanisms. Although considerable work focuses on PD and decisions involving risk and reward, in this Opinion article we propose that the emerging findings in perceptual decision-making highlight the multisystem nature of PD, and that unraveling the neuronal circuits underlying perceptual decision-making impairment may help in understanding other cognitive impairments in people with PD. We also discuss how a decision-making framework may be extended to gain insights into mechanisms of motor impairments in PD.

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Citations

Oct 12, 2019·Brain : a Journal of Neurology·Brónagh McCoyJan Theeuwes
Aug 4, 2018·Frontiers in Psychology·Brenda L Connors, Richard Rende
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yasmine El-Shamayleh, Gregory D Horwitz
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Jan 19, 2021·Journal of Patient Experience·Cynthia Sarabia-TapiaMayela Rodríguez-Violante
May 11, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayan HusseinGeorge W Huntley

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