Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
E C AguilarJ I Alvarez-Leite

Abstract

Pequi is the fruit of Caryocar brasiliense and its oil has a high concentration of monounsaturated and saturated fatty acids, which are anti- and pro-atherogenic agents, respectively, and of carotenoids, which give it antioxidant properties. Our objective was to study the effect of the intake of a cholesterol-rich diet supplemented with pequi oil, compared to the same diet containing soybean oil, on atherosclerosis development, and oxidative stress in atherosclerosis-susceptible LDL receptor-deficient mice (LDLr(-/-), C57BL/6-background). Female mice were fed a cholesterol-rich diet containing 7% soybean oil (Soybean group, N = 12) or 7% pequi oil (Pequi group, N = 12) for 6 weeks. The Pequi group presented a more atherogenic lipid profile and more advanced atherosclerotic lesions in the aortic root compared to the Soybean group. However, the Pequi group presented a less advanced lesion in the aorta than the Soybean group and showed lower lipid peroxidation (Soybean group: 50.2 ± 7.1; Pequi group: 30.0 ± 4.8 µmol MDA/mg protein) and anti-oxidized LDL autoantibodies (Soybean group: 35.7 ± 9.4; Pequi group: 15.6 ± 3.7 arbitrary units). Peritoneal macrophages from the Pequi group stimulated with zymosan showed a reduction in the r...Continue Reading

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Citations

Mar 8, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E C AguilarJ I Alvarez-Leite
Jun 21, 2016·Journal of Ethnopharmacology·Patrícia Rosane Leite de FigueiredoIrwin Rose de Alencar Menezes
May 11, 2019·Journal of Medicinal Food·Nara Rúbia Rodrigues do Nascimento-Silva, Maria Margareth Veloso Naves
Jul 16, 2020·Nutrients·Abigail E CullenJavier Fernandez andGloria Salazar
Apr 10, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Armando Jorge JuniorCândida Aparecida Leite Kassuya

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