PMID: 3756859Oct 1, 1986Paper

Paradoxical effect of three-day thymectomy on sarcogenesis in the mouse with different dosages of methylcholanthrene

Cancer Research
L M Prehn, A Kojima

Abstract

Past studies have shown that thymectomy in the mouse at 3 days of age but not at birth or after 7 days produces, in later life, a variety of localized autoimmune lesions. In the present work, 3-day thymectomy facilitated subsequent sarcogenesis by low dosages of 3-methylcholanthrene but inhibited oncogenesis by a high dosage. If the presence of autoimmunity implies an increased antitumor immunity, it then follows that increased immunity facilitated low-dose sarcogenesis but inhibited sarcogenesis with a high dose.

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