PMID: 3753548Aug 1, 1986Paper

Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil

Atherosclerosis
D R SullivanG R Thompson

Abstract

Twenty-three hypertriglyceridaemic patients treated with 15 g/day of a fish oil concentrate (Maxepa) showed the expected reduction in serum triglyceride concentration but levels of LDL apoprotein B (apoB), measured by radial immunodiffusion, increased significantly. Increases in LDL apoB did not correlate with lipoprotein phenotype or changes in serum triglyceride. Studies in eight normal volunteers demonstrated that the effect of fish oil on LDL apoB was not restricted to hypertriglyceridaemic subjects. In view of the evidence that LDL apoB may be a risk factor for coronary heart disease these findings raise questions regarding the use of fish oil in the treatment of hypertriglyceridaemia.

References

May 12, 1975·Analytical Biochemistry·T G RedgraveC E West
Aug 1, 1978·The American Journal of Clinical Nutrition·T O von LossonczyR J Hermus
May 9, 1985·The New England Journal of Medicine·D KromhoutC de Lezenne Coulander
Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T A SandersG R Thompson
Dec 1, 1984·The Journal of Clinical Investigation·J ShepherdH G Morgan
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B TengP O Kwiterovich
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D R IllingworthW E Connor
Jul 1, 1984·The Journal of Clinical Investigation·P J NestelR Boston
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
Dec 1, 1982·Annals of Internal Medicine·A D SnidermanP O Kwiterovich

❮ Previous
Next ❯

Citations

Aug 15, 1988·Klinische Wochenschrift·T DemantC J Packard
Dec 1, 1989·Atherosclerosis·A M DartM F Oliver
Jan 1, 1994·Pharmacology & Therapeutics·A Semplicini, R Valle
Oct 1, 1988·Journal of the American College of Cardiology·B Q ZhuW W Parmley
Apr 16, 1998·Trends in Genetics : TIG·R V Farese, J Herz
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·T A Sanders
Mar 10, 2004·The British Journal of Nutrition·Pujitha P de SilvaSukhinder Kaur Cheema
Jan 1, 1988·Nutrition Research Reviews·T A Sanders
Jan 1, 1995·Nutrition Research Reviews·B A Griffin, A Zampelas
Sep 1, 1988·The Proceedings of the Nutrition Society·B Lewis
Feb 8, 2011·Journal of Cardiovascular Pharmacology·Kevin C MakiJohn W Marshall
Apr 1, 1992·Journal of Clinical Pharmacy and Therapeutics·C M Florkowski, R Cramb
Oct 1, 1990·Australian and New Zealand Journal of Medicine·L A SimonsS Balasubramaniam
Mar 15, 1993·Annals of the New York Academy of Sciences·D R Illingworth, E B Schmidt
Jun 17, 1989·BMJ : British Medical Journal·A Haines, T A Sanders
Mar 1, 1987·British Heart Journal·T A Sanders
May 11, 2010·The American Journal of Cardiology·Kevin C MakiUNKNOWN COMBination of prescription Omega-3 with Simvastatin (COMBOS) Investigators
Sep 1, 1995·Metabolism: Clinical and Experimental·S E Kasim-KarakasR Almario
Oct 1, 1990·Atherosclerosis·J S Parks, L L Rudel
Sep 9, 2008·International Journal of Cardiology·Guy D EslickAlan Bensoussan
Mar 3, 1988·The New England Journal of Medicine·A Leaf, P C Weber
Jun 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Samman
Jan 1, 2011·Nutrition and Metabolic Insights·Pratibha DubeySukhinder K Cheema
Apr 28, 2010·Nature Reviews. Endocrinology·Allan SnidermanJacqueline de Graaf
Dec 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C ContacosD R Sullivan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.