Paradoxical kinesia in parkinsonism is not caused by dopamine release. Studies in an animal model

Archives of Neurology
K A KeefeE M Stricker

Abstract

Rats become akinetic after large dopamine-depleting brain lesions, yet they show an activation-induced restoration of motor function. In this study, rats were given intraventricular injections of the neurotoxin 6-hydroxydopamine to permanently reduce the dopamine content of the corpus striatum by 98%. Although the rats were akinetic in their home cages, they swam effectively when placed in deep water and escaped from a shallow floating ice bath. These behaviors were not abolished by pretreating the animals with the dopamine antagonists haloperidol and SCH-23390. In contrast, haloperidol completely blocked the brain-damaged animals' behavioral responses to amphetamine. These results suggest that the paradoxical kinesia of dopamine-depleted rats is not a consequence of dopamine release from residual dopaminergic fibers.

Citations

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S SzczypkaR D Palmiter
Apr 9, 2005·Experimental Neurology·Nadine P Poulton, Gillian D Muir
Oct 5, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Ilana SchlesingerDavid Yarnitsky
Jan 17, 2004·The European Journal of Neuroscience·Mathias PessiglioneLéon Tremblay
Jul 31, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Anna Mura, Joram Feldon
May 6, 2016·PloS One·Marc HerbinPierre-Paul Vidal
Apr 5, 2003·Journal of Neurochemistry·Ann D CohenMichael J Zigmond
Jan 12, 2019·Behavioural Pharmacology·Nayara C B BarrocaAmanda R de Oliveira
Aug 31, 2018·Brain : a Journal of Neurology·Thushara PereraWesley Thevathasan
May 12, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V V Cozac, L Rotaru
Jan 7, 2020·Annual Review of Psychology·Roy A Wise, Mykel A Robble
Jun 23, 2018·Neurobiology of Disease·Wesley Thevathasan, Elena Moro
Jun 25, 2010·Neurology·Wesley Thevathasan, Tipu Aziz

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