Abstract
Nocturnal dominance of the incidence of spontaneous ventricular tachyarrhythmias has been reported in patients with Brugada syndrome (BrS). The purpose of the present study is to analyze the QT dynamics and autonomic balance as well as their diurnal variations in BrS patients. Of the 33 consecutive patients with BrS included in the study, 14 had a history of cardiopulmonary arrest due to spontaneous ventricular fibrillation (VF) episodes (VF-BrS) and 19 had asymptomatic BrS (A-BrS). QT dynamics and heart rate variability were analyzed using 24-h Holter electrocardiogram recordings. Of the total 14 first cardiopulmonary arrest episodes due to spontaneous VF, 11 (79%) occurred in VF-BrS patients during the nighttime or at rest. The QT/RR slope during daytime was significantly steeper than that during nighttime in the A-BrS patients (p=0.031), but not in the VF-BrS patients (p=1.0). There were significant diurnal differences pertaining to the high-frequency (HF) and low-frequency (LF)/HF ratios in the A-BrS patients (p=0.019 and p=0.019, respectively), but not in the VF-BrS patients (p=1.0 and p=1.0, respectively). The VF-BrS patients were characterized by relatively high LF/HF ratios, whereas the A-BrS patients were characterized...Continue Reading
References
May 6, 1997·Circulation·H KasanukiS Hosoda
May 20, 1998·American Heart Journal·K MiwaH Inoue
Apr 23, 1999·European Heart Journal·K MatsuoK Shimomura
Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group
Jul 26, 2002·Journal of Cardiovascular Electrophysiology·Juha S PerkiömäkiArthur J Moss
Apr 16, 2003·Circulation·Koonlawee NademaneeStanley P Azen
Jun 17, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Kiyoshi NakazawaShinichi Kobayashi
Oct 3, 2003·European Heart Journal·Rungroj KrittayaphongCharuwan Kangkagate
Nov 14, 2003·European Heart Journal·Jean-Sylvain HermidaPhilippe Coumel
Jun 4, 2004·Journal of Cardiovascular Electrophysiology·Koichi MizumakiHiroshi Inoue
Nov 3, 2004·Circulation·Peter KiesPaolo G Camici
Feb 17, 2007·Pacing and Clinical Electrophysiology : PACE·Bertrand PierreLaurent Fauchier
Jun 8, 2007·Journal of Cardiovascular Electrophysiology·Koichi MizumakiHiroshi Inoue
Jun 9, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Takeshi OhgoWataru Shimizu
Jul 31, 2007·Journal of the American College of Cardiology·Masahiro OgawaPeng-Sheng Chen
May 9, 2008·The New England Journal of Medicine·Michel HaïssaguerreJacques Clémenty
Jun 17, 2008·Journal of Cardiovascular Electrophysiology·Iwona CygankiewiczUNKNOWN MUSIC Investigators
Aug 16, 2008·The New England Journal of Medicine·Maurizio PieroniFilippo Crea
Jul 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mutsuko SangawaKengo F Kusano
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pieter G PostemaArthur A M Wilde
Oct 2, 2009·Journal of Cardiovascular Electrophysiology·Miki YokokawaWataru Shimizu
Feb 6, 2010·Journal of Cardiovascular Electrophysiology·Anna KostopoulouDennis Cokkinos
Feb 6, 2014·Journal of cardiology·Takehito TokuyamaYasuki Kihara