PMID: 2110954Feb 1, 1990Paper

Paradoxical reactions to rectal midazolam as premedication in children

International Journal of Oral and Maxillofacial Surgery
J A RoelofseJ J Joubert

Abstract

Eighty healthy children, between the ages of 2 and 7 years, who were to undergo oral surgical procedures under general anaesthesia, were allocated randomly to 4 groups. Three groups received rectal midazolam, and the other group a placebo (saline) as premedication 30 min prior to induction of anaesthesia. Group A children received midazolam 0.25 mg/kg, Group B 0.35 mg/kg and Group C 0.45 mg/kg. No statistically significant difference was found between the treatment groups as to the effect on systolic- (p = 0.6920) and diastolic (p = 0.8701) blood pressures, respiration (p = 0.0505) and pulse (p = 0.6192) rates at either pre- or post-sedation levels. However, the results indicate that levels of anxiolysis and sedation were significantly associated with midazolam dosage (p less than 0.0001).

References

Jan 1, 1979·British Journal of Clinical Pharmacology·J R Wittenborn
Jun 1, 1987·International Journal of Oral and Maxillofacial Surgery·P Van der BijlH S Breytenbach
Jul 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P van der BijlJ J Joubert
Nov 1, 1986·Anesthesiology·C Saint-MauriceG Olive

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Citations

Feb 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L D ScheepersJ P McCormack
Oct 1, 1990·Anaesthesia·J A Roelofse, J J Joubert
Jun 5, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Chung Hyun TaeJae J Kim
Jul 26, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hani F BraidyVincent B Ziccardi
Sep 16, 2006·Paediatric Anaesthesia·Anuradha PatelHenry Bennett
Oct 6, 2004·Pharmacotherapy·Carissa E MancusoMichael Gabay
Mar 9, 2010·Thérapie·Claire ChevreuilUNKNOWN Groupe d'Etude Interdisiplinaire de Bretagne Psychotropes chez l'enfant et l'adolescent
Jan 7, 1998·Clinical Pediatrics·M MassanariL J Reinstein
Aug 2, 2013·Korean journal of anesthesiology·Young Hee ShinJung Hee Choi
Mar 2, 2016·Current Opinion in Anaesthesiology·Mark G RobackRobert M Kennedy
Mar 12, 2020·Journal of Dental Anesthesia and Pain Medicine·Shreyans Aditya JainSudhindra Baliga
Feb 23, 2021·The American Journal of Clinical Hypnosis·Enrico FaccoGastone Zanette
Apr 11, 2013·Veterinary Anaesthesia and Analgesia·Andrea SánchezFrancisco G Laredo

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