Paradoxical uptake of Gd-EOB-DTPA on the hepatobiliary phase in the evaluation of hepatic metastasis from breast cancer: is the "target sign" a common finding?

Magnetic Resonance Imaging
Sumin HaCheol Min Park

Abstract

The purpose was to describe magnetic resonance imaging (MRI) findings of breast cancer liver metastasis using gadoxetic acid (Gd-EOB-DTPA) with an emphasis on the added value of the hepatobiliary phase (HBP). Nine patients with 13 liver metastases were included in the study after the medical records of 29 breast cancer patients who underwent Gd-EOB-DTPA-enhanced MRI between February 2008 and June 2010 were reviewed. The diagnoses of liver metastasis were established by percutaneous liver biopsy or surgery and on the basis of image findings. Two radiologists retrospectively evaluated signal intensity (SI) and sizes of metastases and patterns of enhancement in an HBP. The SI ratio was calculated as the SI of the central hyperintense portion in "target" lesions divided by the SI of nearby normal liver parenchyma on the HBP. We also measured apparent diffusion coefficient (ADC) values from Diffusion Weighted Image (DWI). Liver metastases were all hypointense [n=13/13 (100%)] on T1-weighted imaging (WI), and many lesions had a "target" appearance with a central high SI and a peripheral low SI rim (47%) on T2WI. Dynamic study showed rim enhancement on the arterial phase (85%) and a "target" appearance, consisting of a central enhanci...Continue Reading

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Citations

Sep 29, 2015·Expert Review of Gastroenterology & Hepatology·António P MatosRichard C Semelka
Dec 3, 2014·Journal of Magnetic Resonance Imaging : JMRI·Kartik S Jhaveri, Hooman Hosseini-Nik
Jan 15, 2014·Expert Review of Gastroenterology & Hepatology·Ahmed Ba-SsalamahFilipe Caseiro Alves
Dec 14, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nobuhiro FujitaHiroshi Honda
Jun 7, 2017·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Elena P ScaliSilvia D Chang
Jan 13, 2021·Insights Into Imaging·Federica VernuccioGiuseppe Brancatelli

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