PMID: 12757575May 22, 2003Paper

Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome

Journal of the American Geriatrics Society
Arduino A MangoniStephen H D Jackson

Abstract

To elucidate the pathophysiological mechanism of the vasodepressor form (VD) of carotid sinus syndrome (CSS) by maneuvers designed to induce generalized sympathetic activation after baroreceptor unloading (lower body negative pressure, LBNP) or direct peripheral adrenoreceptor stimulation via local administration of norepinephrine (NA). Subjects were identified with VD of CSS through diagnostic testing. Research laboratory. Eleven young controls (YC) (mean age +/- standard error of mean = 22.8 +/- 0.7), eight elderly controls (EC) (72.6 +/- 0.6), and eight elderly patients with VD (78.7 +/- 1.7). Forearm arterial blood flow (FABF) was measured in the left and right arms by venous occlusion plethysmography. Measurements were performed during baseline conditions, LBNP (-20 mmHg), and intra-arterial NA infusion in the left brachial artery at three progressively increasing rates (60, 120, and 240 pmol/min). During LBNP, FABF significantly decreased in YC (baseline 3.61 +/- 0.30 vs -20 mmHg 2.96 +/- 0.24 mL/100 g/min, P =.030) and EC (4.05 +/- 0.74 vs 3.69 +/- 0.65 mL/100 g/min, P =.033) but increased in elderly patients with VD (3.65 +/- 0.60 vs 4.54 +/- 0.80 mL/100 g/min, P =.020). During NA infusion, a significant forearm vasocon...Continue Reading

References

Sep 1, 1978·The American Journal of Cardiology·P F WalterE R Dorney
Dec 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M L SmithD L Eckberg
Jan 1, 1985·Journal of Cardiovascular Pharmacology·G ManciaA Zanchetti
Mar 1, 1989·Progress in Cardiovascular Diseases·B StrasbergJ Agmon
May 1, 1984·American Heart Journal·D S Goldstein, H R Keiser
Jan 1, 1994·Pharmacology & Therapeutics·R R Ruffolo, J P Hieble
Oct 1, 1993·Journal of Cardiovascular Electrophysiology·R F Rea, M D Thames
Jun 29, 2001·Experimental Physiology·R van HoeyweghenE Kirkman

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Citations

Nov 7, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maw Pin TanSteve W Parry
Sep 9, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maw Pin TanSteve W Parry
Jan 26, 2005·Journal of the American Geriatrics Society·Allan MooreDeclan Lyons
Jan 11, 2013·Anesthesia and Analgesia·Michel E van GenderenJasper van Bommel
Jun 21, 2014·Journal of the American Heart Association·Maw Pin TanSteve W Parry

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