Paraesthesiae induced by prolonged high frequency stimulation of human cutaneous afferents

The Journal of Physiology
Matthew C KiernanD Burke

Abstract

1. The present study has explored the behaviour of human cutaneous afferents following conduction of prolonged trains of impulses at 200 Hz for 10-20 min, correlating the resultant changes in excitability with the perception of paraesthesiae. 2. Tetanization for 10 min resulted in activity-dependent changes in axonal excitability, with an initial period of hyperexcitability, followed by a long-lasting subexcitability. All subjects experienced paraesthesiae soon after cessation of the tetanic train, and these subsided gradually over 16 min. 3. Longer tetanic trains of 20 min duration resulted in greater changes in axonal excitability, but with paraesthesiae of a similar time course. The post-tetanic increase in excitability was abolished when short tetanic trains were delivered > 30 min before long trains, but all subjects still experienced paraesthesiae. 4. Threshold distributions following tetanic stimulation for both 10 and 20 min established that all axons contributing to the sensory volley underwent a uniform pattern of post-tetanic threshold changes. There was no evidence of a bimodal distribution with some axons hyperpolarized and others depolarized, as occurs with motor axons. However, the excitability changes were grade...Continue Reading

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Citations

May 9, 2003·Archives of Physical Medicine and Rehabilitation·Michael I WeintraubUNKNOWN Magnetic Research Group
Aug 23, 2003·Journal of Psychosomatic Research·H Suarez-RocaW Maixner
Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D BurkeH Bostock
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Mar 2, 2002·Brain : a Journal of Neurology·Matthew C KiernanHugh Bostock
May 18, 2004·The Journal of Physiology·Matthew C KiernanDavid Burke
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Feb 19, 2000·Muscle & Nerve·I MogyorosD Burke
Oct 19, 2011·Journal of the Peripheral Nervous System : JPNS·Susanna B ParkMatthew C Kiernan
Sep 12, 2019·Journal of Neural Engineering·Cynthia K OverstreetEdward W Keefer
Nov 28, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Jeffrey E ArleKristen W Carlson

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