Parafoveal Nonperfusion Analysis in Diabetic Retinopathy Using Optical Coherence Tomography Angiography

Translational Vision Science & Technology
Brian D KrawitzToco Y P Chui

Abstract

To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with nonproliferative diabetic retinopathy (NPDR), and 15 with proliferative diabetic retinopathy (PDR) were imaged with 10 macular OCTA scans. PICAs were automatically delineated on the averaged superficial OCTA images. Following creation of an eccentricity-specific reference database from the controls, all PICAs greater than 2 SD above the reference means for PICA area and minor axis length were identified as nonperfused areas. Regions of interest (ROI) at 300 μm and 1000 μm from the foveal avascular zone (FAZ) margin were analyzed. Percent nonperfused area was defined as summed nonperfused areas divided by ROI area. Values were compared using Kruskal-Wallis and post-hoc Mann-Whitney U tests. Median values for total percent nonperfused area at the 300-μm ROI were 2.09, 2.44, 18.08, and 27.55 in the control, noDR, NPDR, and PDR groups, respectively. Median values at the 1000-μm ROI were 3.10, 3.31, 13.42, and 23.00. While there were no ...Continue Reading

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Citations

Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
May 12, 2020·Investigative Ophthalmology & Visual Science·Sonja G KarstEduardo V Navajas
Aug 29, 2020·Translational Vision Science & Technology·Julian LoMarinko V Šarunić
Oct 6, 2020·Biomedical Optics Express·Acner CaminoYifan Jian
Aug 18, 2020·Case Reports in Ophthalmological Medicine·Carl S WilkinsStephanie Llop
Jan 29, 2019·Translational Vision Science & Technology·Taly Gilat SchmidtJoseph Carroll
Jan 30, 2021·European Journal of Ophthalmology·Emine Temel, Figen Batıoğlu
Oct 27, 2020·Translational Vision Science & Technology·Jessica A KrakerRachel E Linderman
Jun 15, 2021·Biomedical Optics Express·Davis B ZhouToco Y P Chui

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Software Mentioned

MATLAB
R ( R Foundation for Statistical Computing
ImageJ
Adobe Photoshop
OCTA
Excel

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