Paraganglioma with highly malignant potential involving the rib - Case report and review of the literature.

Radiology Case Reports
Yong JiaIain D C Kirkpatrick

Abstract

Paragangliomas are rare neuroendocrine tumors arising from paraganglion cells in sympathetic or parasympathetic chains, which may develop in the abdomen, chest, skull base, and neck. As paragangliomas have a wide range of imaging features, the diagnosis often requires tissue sampling. We present a unique case of a paraganglioma which originally presented as a rib tumor. A 64-year-old male with right flank pain for 2 months' was referred for a noncontrast renal colic CT. He was found to have a 3.7 × 3.5 cm soft tissue mass invading the left posterior 9th rib and paraspinal muscle. This was fluorodeoxyglucose F 18, (18F-FDG) avid, with no other distant metabolic activity. He underwent ultrasound-guided core biopsy which revealed a diagnosis of paraganglioma. A right thoracotomy with chest wall resection of 8, 9, and 10 ribs were subsequently performed. The tumor was removed along with a small portion of adherent lung. The tumor was positive for CD56, synaptophysin and chromogranin. S-100 highlighted occasional sustentacular cells, consistent with a pathologic diagnosis of a paraganglioma. The patient remains symptom free for 6 months' after the operation. Our case highlights that, when paragangliomas occur within the chest wall, ...Continue Reading

References

Mar 1, 1977·Archives of Surgery·J J SmalleyC P Nichols
Aug 23, 2001·The Annals of Thoracic Surgery·G RakovichA Duranceau
May 10, 2002·The New England Journal of Medicine·Hartmut P H NeumannUNKNOWN Freiburg-Warsaw-Columbus Pheochromocytoma Study Group
Nov 15, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ukihide TateishiNoriyuki Moriyama
Nov 15, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ukihide TateishiNoriyuki Moriyama
Oct 16, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Michael A BlakeGiles W Boland
Jul 25, 2006·AJR. American Journal of Roentgenology·Ki Yeol LeeNam Joon Lee
Mar 23, 2007·AJR. American Journal of Roentgenology·Jonathan BalcombeWallace T Miller
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri J L M TimmersKarel Pacak
Oct 23, 2013·Seminars in Diagnostic Pathology·Thomas G PapathomasArthur S Tischler
Jun 24, 2014·Clinical Endocrinology·Juan P BritoMohammad H Murad
May 23, 2015·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Mariaelena OcchipintiAlexander A Bankier
May 31, 2015·Japanese Journal of Radiology·Yoko TakashimaHiroshi Honda
Nov 29, 2015·Hematology/oncology Clinics of North America·Lauren Fishbein
Nov 29, 2017·Seminars in Ultrasound, CT, and MR·Daniel OcazionezCarlos S Restrepo
Dec 15, 2017·Histopathology·John TurchiniAnthony J Gill
Aug 29, 2018·Journal of Clinical Medicine·Noriko KimuraMitsuhide Naruse
Sep 16, 2018·Journal of Clinical Medicine·Sylvia L AsaOzgur Mete
Nov 2, 2019·Surgical Pathology Clinics·Julie Guilmette, Peter M Sadow

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