PMID: 641198Mar 1, 1978Paper

Paraganglioneuroma of the duodenum: an evolutionary hybrid?

Journal of Clinical Pathology
T Cooney, E C Sweeney

Abstract

On light microscopy the neural component of a hybrid neural and endocrine duodenal tumour was characterised by ganglion cells and the endocrine component by epithelioid cells which were both argentaffin and argyrophil. Spindle-shaped cells of indeterminant lineage were also present. Electron microscopy revealed 'pale' and 'dark' cells, the former corresponding to the epithelioid cells and containing many membrane-bound neurosecretory granules, the latter probably corresponding to the spindle cells and containing large numbers of neurofilaments. Occasional cells contained both neurofilaments and secretory granules arranged in a consistent pattern in the cytoplasm. These composite cells may have represented an incompletely differentiated precursor of both the neural and endocrine elements of the tumour.

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KawaguchiN Goseki
Aug 1, 1993·Digestive Diseases and Sciences·C F JiangS W Tan
Feb 1, 1988·Pathology, Research and Practice·R RanaldiV Suraci
Nov 1, 1982·Gut·S S Fernando, V J McGovern
Sep 28, 2013·Case Reports in Pathology·Vikram NarangHarpreet Puri
Apr 13, 2004·Scandinavian Journal of Gastroenterology·P BucherPh Morel
Dec 2, 2005·Annual Review of Psychology·David F Sherry

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