Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats

American Journal of Respiratory and Critical Care Medicine
E W UhlP K McAllister

Abstract

Parainfluenza type 1 (Sendai) virus infection in young rats induces airway growth abnormalities associated with persistent pulmonary dysfunction and hyperresponsiveness. The objectives of this study were to compare virus-susceptible brown Norway (BN) rats and virus-resistant F344 rats and to determine which of several virus-induced structural abnormalities, including bronchiolar hypoplasia, alveolar dysplasia, bronchiolar mural fibrosis, and increases in bronchiolar mast cells, were associated with virus-induced increases in pulmonary resistance and hyperresponsiveness to methacholine. We also determined whether bronchiolar mural thickening and fibrosis may be caused by increased bronchiolar expression of cytokines such as TGF-beta 1 into airways. BN rats infected with virus developed increases in respiratory resistance and hyperresponsiveness that persisted for 28 to 65 d after inoculation. Functional abnormalities were most strongly associated with bronchiolar mural thickening and fibrosis as well as with recruitment of inflammatory cells, including macrophages, mast cells, lymphocytes, and eosinophils, into the bronchiolar wall. F344 rats were resistant to significant virus-induced alterations in bronchiolar airway wall thic...Continue Reading

Citations

Dec 25, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jose JosephM Gary Nicholls
Dec 28, 1999·Microbes and Infection·S G Reed
Apr 12, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert F Lemanske
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R G Hegele
Jul 28, 2001·Clinical and Experimental Pharmacology & Physiology·D J FernandesA G Stewart
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xuezhong Cai, William L Castleman
Jun 18, 2009·Current Opinion in Allergy and Clinical Immunology·James E Gern
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·G N ColasurdoG L Larsen
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·R L SorknessR F Lemanske
Apr 17, 2004·American Journal of Respiratory and Critical Care Medicine·Christopher C CopenhaverRobert F Lemanske
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·L D MikusR F Lemanske
Nov 1, 2003·American Journal of Respiratory Cell and Molecular Biology·Louis A RosenthalRobert F Lemanske
Jun 15, 2013·American Journal of Respiratory Cell and Molecular Biology·Ronald L SorknessXin Sun
Jun 25, 2003·American Journal of Respiratory Cell and Molecular Biology·Mary P O'SullivanMichael J Holtzman
Oct 19, 1999·The Journal of Clinical Investigation·J A EliasR J Homer
Oct 8, 1999·The Journal of Clinical Investigation·J E GernW W Busse
Aug 24, 2002·Pediatric Research·Ronald L SorknessRobert F Lemanske
Jun 20, 2014·Science Translational Medicine·Shunsuke MinagawaStephen L Nishimura
Jan 24, 2007·Respiratory Physiology & Neurobiology·Rachel A CollinsPeter D Sly
Nov 30, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Jae-Won Oh
Oct 30, 2010·Immunology and Allergy Clinics of North America·Louis A Rosenthal
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Gary L LarsenWayne Morgan
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·James E GernRobert F Lemanske
Mar 24, 2004·Integrative Cancer Therapies·C Murray Ardies
Aug 15, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ronald L SorknessLouis A Rosenthal
Sep 13, 2011·Expert Review of Anti-infective Therapy·Pingsheng Wu, Tina V Hartert
Nov 5, 2003·Journal of Applied Physiology·Ronald L Sorkness, Amjad Tuffaha
Sep 5, 2019·International Journal of Molecular Sciences·Jean S MarshallEdwin Leong
May 10, 2020·Journal of Leukocyte Biology·Kim S LeMessurierAmali E Samarasinghe
Jun 21, 2011·Immunological Reviews·Monica L GavalaJames E Gern
Sep 1, 1999·International Journal of Experimental Pathology·R AgarwalA S Mustafa
Mar 21, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H MochizukiA Morikawa
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T H Lee
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xuezhong Cai, William L Castleman
Dec 6, 2018·Viruses·Mingyuan HanMarc B Hershenson
Nov 18, 2020·Respiratory Medicine Case Reports·Anna Flavia Ribeiro Dos Santos MiggiolaroLucia de Noronha
Jul 25, 2000·Clinics in Chest Medicine·A TuffahaR F Lemanske
Jul 1, 1998·Seminars in Pediatric Infectious Diseases·Kelly J Henrickson

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