Parallel activation of field CA2 and dentate gyrus by synaptically elicited perforant path volleys

Hippocampus
R Bartesaghi, Tiziana Gessi

Abstract

Previous studies showed that dorsal psalterium (PSD) volleys to the entorhinal cortex (ENT) activated in layer II perforant path neurons projecting to the dentate gyrus. The discharge of layer II neurons was followed by the sequential activation of the dentate gyrus (DG), field CA3, field CA1. The aim of the present study was to ascertain whether in this experimental model field, CA2, a largely ignored sector, is activated either directly by perforant path volleys and/or indirectly by recurrent hippocampal projections. Field potentials evoked by single-shock PSD stimulation were recorded in anesthetized guinea pigs from ENT, DG, fields CA2, CA1, and CA3. Current source-density (CSD) analysis was used to localize the input/s to field CA2. The results showed the presence in field CA2 of an early population spike superimposed on a slow wave (early response) and of a late and smaller population spike, superimposed on a slow wave (late response). CSD analysis during the early CA2 response showed a current sink in stratum lacunosum-moleculare, followed by a sink moving from stratum radiatum to stratum pyramidale, suggesting that this response represented the activation and discharge of CA2 pyramidal neurons, mediated by perforant pat...Continue Reading

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Citations

Dec 14, 2012·PloS One·Magda ChafaiMichel G Desarménien
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David C RowlandClifford G Kentros
Dec 18, 2013·Nature Neuroscience·Keigo KoharaSusumu Tonegawa
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May 17, 2021·Neuropharmacology·Patrick C Andrews, Shashank M Dravid

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