PMID: 1201379Oct 1, 1975Paper

Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aurea

British Journal of Pharmacology
R EndeanN Sopranzi

Abstract

The spectrum of biological activity exhibited by litorin, a bombesin-like nonapeptide found in extracts of the skin of the Australian leptodactylid frog Litoria aurea was compared with that exhibited by the tetradecapeptide bombesin. 2 Litorin proved to be more potent than bombesin on isolated smooth muscle preparations and on the urinary bladder in situ. However, it was less potent on dog systemic blood pressure and kidney vasculature activation of the renen-angiotensin system being slight or lacking. 3 Gastrin release and acid secretion produced by litorin was more rapid in onset but less intense and less sustained than that elicited by bombesin. The same could be observed for pancreatic secretion. 4 Gall bladder contraction stimulated by litorin was probably caused by a double action of the peptide, directly on the bladder smooth muscle, and indirectly by cholecystokinin release. 5 In its effects on the myo-electric activity of the dog duodenum (inhibition of spikes and increase in frequency of pacesetter potentials leading to the appearance of a sequence of slow and small potentials) litorin possessed approximately 50 to 70% of the activity of bombesin.

References

Jun 18, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·V ErspamerR Endean
Jul 1, 1972·British Journal of Pharmacology·V ErspamerN Sopranzi
Jul 1, 1973·British Journal of Pharmacology·V ErspamerN Sopranzi
Oct 1, 1974·British Journal of Pharmacology·G BertacciniN Sopranzi
Oct 1, 1974·British Journal of Pharmacology·V ErspamerN Sopranzi
Nov 1, 1973·British Journal of Pharmacology·G BertacciniM Impicciatore

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Citations

Nov 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·N E Babskaia
May 20, 1985·European Journal of Pharmacology·J MizrahiD Regoli
Jan 1, 1982·Regulatory Peptides·J H WalshG L Rosenquist
Oct 1, 1975·British Journal of Pharmacology·M BroccardoR de Castiglione
Nov 1, 1973·The Journal of Pharmacy and Pharmacology·M Impicciatore, G Bertaccini
Sep 20, 1979·World Journal of Surgery·N BassoV Speranza
May 1, 1988·Digestive Diseases and Sciences·T TollströmB Pernow
Sep 6, 2006·Toxicon : Official Journal of the International Society on Toxinology·Barbara J Hawgood
Feb 22, 2002·Rapid Communications in Mass Spectrometry : RCM·Stephen McCleanW Franklin Smyth
Jan 1, 1985·Annals of the New York Academy of Sciences·P J Kulkosky
Apr 1, 1984·The Journal of Pharmacy and Pharmacology·G Falconieri ErspamerT Nakajima
Jul 1, 1980·The Journal of Pharmacy and Pharmacology·G F Erspamer, D Piccinelli

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