Parallel declines in Fos activation of the medial anteroventral periventricular nucleus and LHRH neurons in middle-aged rats

Endocrinology
W W LeG E Hoffman

Abstract

The middle-age decline in reproductive function is manifested by reduced LHRH release, resulting in a decreased magnitude and delay of onset of the LH surge. Earlier studies suggested that the reductions in LHRH neural activation in middle-aged rats resulted from deficits in the afferent drive to the LHRH neurons. One critical afferent to the LHRH neurons lies in the anteroventral periventricular preoptic area (AVPv) nucleus. The neurons of the medial AVPv are synchronously activated to express Fos with LHRH neurons at the time of an LH surge in young adult animals. The present study examined whether, in middle age, reductions in the activation of AVPv neurons accompany the reduction in Fos activation in LHRH neurons. Young (3- to 4-month-old) and middle-aged (10- to 12-month-old) spontaneously cycling and ovariectomized steroid-replaced rats were killed during peak and early descending phase of the LH surge, and their brains were examined for Fos in LHRH and AVPv neurons. Young animals had a characteristic increase in Fos expression in both LHRH and AVPv neurons. In middle-aged rats, the proportion of LHRH neurons expressing Fos at the time of an LH surge was reduced by approximately 50%, irrespective of whether surges were sp...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W S LeeG E Hoffman
Nov 1, 1988·Brain Research. Developmental Brain Research·R E WatsonG E Hoffman
Jun 1, 1983·Endocrinologia Japonica·E Terasawa, G A Davis
Mar 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·P M Wise
Oct 1, 1980·Biology of Reproduction·R L CooperR F Walker
Dec 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K A BerghornG E Hoffman
Jul 1, 1993·Frontiers in Neuroendocrinology·G E HoffmanJ G Verbalis

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Citations

May 11, 2012·Biology of Reproduction·Cary L DickenGenevieve Neal-Perry
Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter
Dec 31, 2010·Endocrinology·Sarah M DickersonAndrea C Gore
Jun 24, 2010·Maturitas·Genevieve Neal-PerryCary Dicken
Dec 10, 2008·Molecular and Cellular Endocrinology·Jodi L Downs, Phyllis M Wise
Dec 8, 2004·Experimental Gerontology·Mary Ann OttingerGian Carlo Panzica
Feb 1, 2011·Toxicology and Applied Pharmacology·Sarah M DickersonAndrea C Gore
Aug 23, 2003·Endocrinology·Tandra R ChakrabortyAndrea C Gore
Dec 25, 2004·Experimental Biology and Medicine·Tandra R ChakrabortyAndrea C Gore
Jun 26, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiaoli WangLing Chen
May 4, 2021·Neuropeptides·Eleni AngelopoulouValérie Simonneaux

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