Parallel Development of Chromatin Patterns, Neuron Morphology, and Connections: Potential for Disruption in Autism

Frontiers in Neuroanatomy
Miguel Á García-CabezasBasilis Zikopoulos

Abstract

The phenotype of neurons and their connections depend on complex genetic and epigenetic processes that regulate the expression of genes in the nucleus during development and throughout life. Here we examined the distribution of nuclear chromatin patters in relation to the epigenetic landscape, phenotype and connections of neurons with a focus on the primate cerebral cortex. We show that nuclear patterns of chromatin in cortical neurons are related to neuron size and cortical connections. Moreover, we point to evidence that reveals an orderly sequence of events during development, linking chromatin and gene expression patterns, neuron morphology, function, and connections across cortical areas and layers. Based on this synthesis, we posit that systematic studies of changes in chromatin patterns and epigenetic marks across cortical areas will provide novel insights on the development and evolution of cortical networks, and their disruption in connectivity disorders of developmental origin, like autism. Achieving this requires embedding and interpreting genetic, transcriptional, and epigenetic studies within a framework that takes into consideration distinct types of neurons, local circuit interactions, and interareal pathways. Th...Continue Reading

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Citations

Sep 27, 2018·Journal of Neurophysiology·Helen BarbasMiguel Ángel García-Cabezas
May 11, 2019·PLoS Biology·Miguel Ángel García-Cabezas, Basilis Zikopoulos
Jun 21, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine J Charvet
Mar 27, 2020·International Journal of Molecular Sciences·Magdalena MeyerBenjamin Jurek
Sep 8, 2018·Acta Neuropathologica·Basilis ZikopoulosHelen Barbas
Mar 15, 2019·Acta Neuropathologica Communications·Iris Margalit TrutzerBasilis Zikopoulos
Feb 11, 2019·Brain Structure & Function·Miguel Ángel García-CabezasHelen Barbas
Oct 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharon M Kolk, Pasko Rakic

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Methods Mentioned

BETA
electron microscopy
acetylation

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