DOI: 10.1101/475806Nov 24, 2018Paper

Parallel Distributed Networks Resolved at High Resolution Reveal Close Juxtaposition of Distinct Regions

BioRxiv : the Preprint Server for Biology
Rodrigo M BragaRandy L Buckner


Examination of large-scale distributed networks within the individual reveals details of cortical network organization that are absent in group-averaged studies. One recent discovery is that a distributed transmodal network, often referred to as the 'default network', is comprised of two separate but closely interdigitated networks, only one of which is coupled to posterior parahippocampal cortex. Not all studies of individuals have identified clear separation of the same networks. Here, functional MRI (fMRI) participants (n=2; human; females) scanned intensively across 31 sessions again revealed the two intertwined networks. The networks were observed across analytical (seed-based connectivity and parcellation) and data projection (volume and surface) methods. To gain further insight into the anatomical details, additional participants (n=3; human; females) were examined with high-resolution (1.35mm) fMRI at 7T. The two networks were identified with separate regions localized to adjacent portions of the cortical ribbon, sometimes with their close juxtaposition evident inside the same sulcus. Anterior and posterior midline regions previously implicated as core hubs of the default network revealed near complete spatial separatio...Continue Reading

Related Concepts

Cerebral Cortex
Hippocampus (Brain)
Magnetic Resonance Imaging
Spatial Distribution
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