Abstract
The mRNA levels of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and interleukin-6 (IL-6) were examined in sural nerves of 22 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). The mRNAs for NGF, GDNF, LIF, and IL-6 were upregulated, whereas CNTF mRNA was downregulated significantly in the nerves. The NGF, GDNF, and CNTF, but not LIF mRNA expressions were parallel to those of the cognate receptors, suggesting that these cognate soluble receptors effectively present these factors to maintain and regenerate the axons. Furthermore, IL-6 mRNA expression was significantly parallel to both binding and signal-transducing receptor expression, implying a role of the IL-6 signal for non-neuronal cells in CIDP. These findings indicate that multiple neurotrophic growth factors and cytokines are expressed cooperatively with their concomitant receptors in the nerve lesions of CIDP and play an important role particularly in nerve repair.
References
Jul 1, 1989·Neurology·G SobueD Pleasure
Jul 1, 1988·Annals of Neurology·G SobueD Pleasure
Jul 1, 1997·Clinical Immunology and Immunopathology·J ZhuH Link
Jun 19, 1998·Brain Research·Y ItoG Sobue
Dec 16, 1998·Brain Research·M YamamotoG Sobue
May 18, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M NagamatsuG Sobue
Aug 14, 1999·Immunology·G DeretziJ Zhu
Sep 17, 1999·Neurology·W M BosboomJ H Wokke
Jul 25, 2000·Brain : a Journal of Neurology·K Murata, M C Dalakas
Mar 7, 2001·Journal of the Neurological Sciences·N HattoriG Sobue
May 22, 2001·Muscle & Nerve·M YamamotoG Sobue
Aug 25, 2001·Brain Research·M YamamotoG Sobue
Citations
May 24, 2007·Histochemistry and Cell Biology·Kazunori SangoShizuka Takaku
Mar 31, 2005·Molecular and Cellular Neurosciences·Tiziana VigoAngelo Schenone
Jan 4, 2013·Stem Cells and Development·Diego PastorSalvador Martínez
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Lucilla NobbioAngelo Schenone
May 24, 2016·EBioMedicine·Raphaël FaucardAlain Créange
Jul 22, 2004·Muscle & Nerve·Bernd C KieseierHans-Peter Hartung
Mar 8, 2006·Journal of the Peripheral Nervous System : JPNS·Richard A C HughesNorman A Gregson
Apr 20, 2007·Neuropathology and Applied Neurobiology·G BodegaB Fernández
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Claudia Sommer, Klaus Toyka
Dec 2, 2004·Brain Research. Brain Research Reviews·Cecilia Vergara, Beatriz Ramirez
Sep 5, 2006·Frontiers in Neuroendocrinology·Markus KippCordian Beyer
May 14, 2011·Acta histochemica·Claudia M Toledo-Corral, Lisa R Banner
Mar 16, 2007·Biochimica Et Biophysica Acta·Toshifumi TanakaToshiaki Hanafusa
Sep 14, 2006·Current Opinion in Neurology·Bernd C KieseierHeinz Wiendl
Jun 26, 2020·Journal of Neuroscience Research·Zuoheng QinJunhua Xiao