Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy

Muscle & Nerve
Masahiko YamamotoG Sobue

Abstract

The mRNA levels of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and interleukin-6 (IL-6) were examined in sural nerves of 22 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). The mRNAs for NGF, GDNF, LIF, and IL-6 were upregulated, whereas CNTF mRNA was downregulated significantly in the nerves. The NGF, GDNF, and CNTF, but not LIF mRNA expressions were parallel to those of the cognate receptors, suggesting that these cognate soluble receptors effectively present these factors to maintain and regenerate the axons. Furthermore, IL-6 mRNA expression was significantly parallel to both binding and signal-transducing receptor expression, implying a role of the IL-6 signal for non-neuronal cells in CIDP. These findings indicate that multiple neurotrophic growth factors and cytokines are expressed cooperatively with their concomitant receptors in the nerve lesions of CIDP and play an important role particularly in nerve repair.

References

Jul 1, 1988·Annals of Neurology·G SobueD Pleasure
May 18, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M NagamatsuG Sobue
Mar 7, 2001·Journal of the Neurological Sciences·N HattoriG Sobue

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Citations

Mar 31, 2005·Molecular and Cellular Neurosciences·Tiziana VigoAngelo Schenone
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Lucilla NobbioAngelo Schenone
Mar 8, 2006·Journal of the Peripheral Nervous System : JPNS·Richard A C HughesNorman A Gregson
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Claudia Sommer, Klaus Toyka
Dec 2, 2004·Brain Research. Brain Research Reviews·Cecilia Vergara, Beatriz Ramirez
May 14, 2011·Acta histochemica·Claudia M Toledo-Corral, Lisa R Banner
Mar 16, 2007·Biochimica Et Biophysica Acta·Toshifumi TanakaToshiaki Hanafusa
Sep 14, 2006·Current Opinion in Neurology·Bernd C KieseierHeinz Wiendl

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