PMID: 2126483Oct 8, 1990Paper

Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway

Brain Research
J SegoviaK Gale

Abstract

Adult male rats were lesioned with 6-hydroxydopamine in order to destroy the nigrostriatal dopaminergic projections. In rats with such a lesion, we found a parallel increase in glutamic acid decarboxylase (GAD) activity and GAD mRNA in the striatum ipsilateral to the lesion at 4 weeks and 4 months after the lesion. These observations support the proposal that nigral dopaminergic neurons exert a tonic inhibitory control over the striatal GABAergic neurons. Our observations also suggest that the dopaminergic neurons can inhibit gene expression in striatal GABAergic neurons and that the enhanced striatal GAD activity following lesions of the dopaminergic projections is due to 'de novo' synthesis of the enzyme.

References

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Citations

Sep 1, 1995·Journal of Computational Neuroscience·R Kötter, J Wickens
Mar 1, 1991·Neurochemical Research·M G Erlander, A J Tobin
Apr 1, 1995·Brain Research. Molecular Brain Research·B A SorgP W Kalivas
Feb 1, 1996·Brain Research. Molecular Brain Research·O ZachrissonN Lindefors
Nov 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·N Lindefors
Oct 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·N J TillakaratneK M Gibson
May 11, 2005·Neurobiology of Disease·Diane T StephensonMarina E Emborg
Oct 23, 1997·Brain Research. Molecular Brain Research·T FalkenbergU Ungerstedt
Jul 17, 1999·Brain Research. Molecular Brain Research·F H LinD A Hosford

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