Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population

British Journal of Pharmacology
Y DumontG Poirier

Abstract

1 The appearance of pancreatic muscarinic receptors during development has been measured by use of the specific ligand [3H]-quinuclidinyl benzilate ([3H]-QNB). 2 QNB binding sites are present in foetal pancreas; their maximal concentration is attained at the age of 30 days and a significant decrease is observed in one year old animals. 3 Affinity of [3H]-QNB for the muscarinic receptor does not change with age. 4 An evaluation of the pancreatic secretory response to a cholinoceptor agonist as a function of age indicates that the development of this response parallels that of the receptor population. 5 It is suggested that, at all ages from 3 days after birth onwards, the maximal secretory response of the exocrine pancreas to a cholinoceptor agonist mobilizes the same proportion of the total population of QNB binding sites.

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Citations

Dec 3, 1981·European Journal of Pharmacology·L LaroseG G Poirier
Jan 1, 1983·Pharmacology & Therapeutics·W Klinger
Jun 12, 2003·Autonomic Neuroscience : Basic & Clinical·Connie A Meacham, Adriel D Johnson
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Jan 7, 2020·Advances in Medical Sciences·Jean Morisset
Jul 15, 1999·Biochemical and Biophysical Research Communications·J BourassaJ Morisset
May 5, 2010·Advances in Medical Sciences·J Morisset

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