PMID: 8594873Dec 1, 1995Paper

Parallel regulation of constitutive NO synthase and renin at JGA of rat kidney under various stimuli

The American Journal of Physiology
H M BosseS Bachmann

Abstract

Four chronic experiments were performed to assess changes in the activity and gene expression of type I nitric oxide synthase (NOS) at the macula densa (MD) and of renin expression and immunoreactivity (IR) at the juxtaglomerular apparatus (JGA) of rat kidney, as follows: 1) two-kidney, one-clip Goldblatt hypertension (2K1C, for 3 and 40 days; sham operation for controls), 2) furosemide treatment (150 mg/kg-1.day-1 ip for 5 days), 3) chronic low-salt diet (0.02%) vs. high-salt diet (3%; both for 11 days), and 4) chronic blockade of NOS by nitro-L-arginine methyl ester (L-NAME, 40 mg.kg-1.day-1 for 2 mo). NOS and renin gene expression, NOS enzyme activity and renin IR were semiquantitatively evaluated with histochemical methods (NADPH diaphorase, in situ hybridization, immunohistochemistry). In 2K1C, marked increases were induced in NOS and renin in the ischemic vs. contralateral kidneys both after 3 and 40 days, respectively (P < 0.05). Related to controls, significant increases in the ischemic kidney were encountered after 3 and 40 days, whereas contralateral suppression of NOS and renin was found only after 40 days. Furosemide treatment resulted in a marked increase of both NOS and renin levels compared with controls (P < 0.0...Continue Reading

Citations

Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J SolhaugK W Dong
Sep 1, 2000·American Journal of Physiology. Renal Physiology·R KomersS Anderson
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Dec 29, 2005·American Journal of Physiology. Renal Physiology·Hui-Fang ChengRaymond C Harris
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S Wilcox
Jun 22, 2006·American Journal of Physiology. Renal Physiology·F TheiligS Bachmann
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Mar 16, 2001·American Journal of Physiology. Renal Physiology·W WeichertS Bachmann
Nov 14, 2002·American Journal of Physiology. Renal Physiology·Andrea HartnerKarl F Hilgers
Oct 11, 2001·American Journal of Physiology. Renal Physiology·I V YosipivS S El-Dahr
May 9, 2003·American Journal of Physiology. Renal Physiology·Radko Komers, Sharon Anderson
Mar 26, 2010·American Journal of Physiology. Renal Physiology·Deyin LuRuisheng Liu
Jun 6, 2012·Pflügers Archiv : European journal of physiology·Jurgen Schnermann, Josephine P Briggs
Dec 23, 2016·American Journal of Physiology. Renal Physiology·K I BlankensteinK Mutig
Feb 8, 2002·American Journal of Physiology. Renal Physiology·K HöcherlA Kurtz
Jan 8, 2005·American Journal of Physiology. Renal Physiology·Wesley MartusWilliam H Beierwaltes
May 18, 2006·American Journal of Physiology. Renal Physiology·Tianxin YangJurgen B Schnermann
Feb 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A PaliegeS Bachmann
Mar 11, 2004·American Journal of Physiology. Renal Physiology·Alex PaliegeTianxin Yang
Nov 4, 2004·American Journal of Physiology. Renal Physiology·Sebastian BachmannSatish Kumar
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Hong JiKathryn Sandberg
Feb 5, 2009·Kidney International·Juliane GadauFranziska Theilig

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