parallel secretion of secretory proteins and calcium by the rat parotid gland

The Journal of Physiology
P Kanagasuntheram, S C Lim

Abstract

1. The secretion of amylase, deoxyribonuclease, ribonuclease, protein and Ca2+ by the rat parotid gland in vitro was studied. 2. Isoproterenol and carbamoylcholine elicited a parallel discharge of amylase, deoxyribonuclease, ribonuclease and protein over a 40 min time period. 3. The composition of the secretion was independent of the secretogogue used for stimulation. When gland slices from the same animal were stimulated with isoproterenol, adrenaline, phenylephrine or carbamoylcholine, secretory enzymes and protein were secreted in constant proportions. 4. 45Ca injected intraperitoneally 16 h before stimulation with either isoproterenol or carbamoylcholine was released in parallel with amylase and protein. 5. The relative proportions of amylase, ribonuclease, deoxyribonuclease, protein and Ca present in isolated parotid gland secretory granules was identical to that of isoproterenol stimulated gland secretion. 6. It is concluded that the secretory proteins and Ca2+ are discharged in constant proportions by the rat parotid gland regardless of the mode of stimulation or the rate of secretion. The similarity in the composition of gland secretion and granule contents also suggests that enzymes and Ca2+ are released by exocytosis ...Continue Reading

Citations

Jan 1, 1995·Fundamental & Clinical Pharmacology·M SaminiP Hassanzadeh
Mar 1, 1995·General Pharmacology·A R DehpourM Abdollahi
Jan 1, 2006·Toxicology Mechanisms and Methods·Abdollah Osman AhmedMohammad Abdollahi
Dec 1, 1992·Archives of Oral Biology·J H Yu, R S Redman
Aug 1, 1983·Journal of Microscopy·G H Cope
Jan 1, 1990·Archives of Oral Biology·R R Sandborg, I A Siegel
Mar 21, 2002·Fundamental & Clinical Pharmacology·M Abdollahi, Z Isazadeh
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammad Abdollahi, Hajar Safarhamidi
Oct 11, 1982·Biochimica Et Biophysica Acta·C Peterfy, A Tenenhouse

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