Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors

Bioorganic & Medicinal Chemistry Letters
Shawn M BauerBing-Yan Zhu

Abstract

Parallel synthesis and iterative optimization led to the discovery of a series of potent and specific factor Xa inhibitors demonstrating excellent in vitro activity with promising pharmacokinetics.

References

Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·K KamataS H Kim
Mar 15, 2000·Journal of Medicinal Chemistry·D K HerronG F Smith
Mar 15, 2000·Journal of Medicinal Chemistry·Y K YeeM R Wiley
Mar 27, 2001·Bioorganic & Medicinal Chemistry Letters·J M FevigR R Wexler
Jul 19, 2001·Bioorganic & Medicinal Chemistry Letters·W D ShraderG Carr
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Yonghong SongBing-Yan Zhu
Feb 5, 2003·Bioorganic & Medicinal Chemistry Letters·Yuo-Ling ChouMonica J Kochanny
Feb 21, 2003·Journal of Medicinal Chemistry·Yong Mi Choi-SledeskiVincent Mikol

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Citations

Mar 12, 2004·Bioorganic & Medicinal Chemistry Letters·Penglie ZhangBing-Yan Zhu
Dec 8, 2009·Medicinal Research Reviews·Yu-Kai Lee, Mark R Player
Nov 15, 2005·Journal of Combinatorial Chemistry·Roland E Dolle

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