Parallel Visual Pathways with Topographic versus Nontopographic Organization Connect the Drosophila Eyes to the Central Brain

IScience
Lorin TimaeusThomas Hummel

Abstract

One hallmark of the visual system is a strict retinotopic organization from the periphery toward the central brain, where functional imaging in Drosophila revealed a spatially accurate representation of visual cues in the central complex. This raised the question how, on a circuit level, the topographic features are implemented, as the majority of visual neurons enter the central brain converge in optic glomeruli. We discovered a spatial segregation of topographic versus nontopographic projections of distinct classes of medullo-tubercular (MeTu) neurons into a specific visual glomerulus, the anterior optic tubercle (AOTU). These parallel channels synapse onto different tubercular-bulbar (TuBu) neurons, which in turn relay visual information onto specific central complex ring neurons in the bulb neuropil. Hence, our results provide the circuit basis for spatially accurate representation of visual information and highlight the AOTU's role as a prominent relay station for spatial information from the retina to the central brain.

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Citations

Nov 19, 2020·ELife·Mai M MorimotoMichael B Reiser
Mar 24, 2021·ELife·Ben J HardcastleMark A Frye
Jun 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Malin, Claude Desplan

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Methods Mentioned

BETA
dissect
dissection

Software Mentioned

MeTu
synGRASP
GRASP
FLYBOW
DenMark

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