PMID: 7032960Aug 1, 1981Paper

Parallelism between the effect of cortisone acetate on hybrid resistance and natural killing

Experimental Hematology
E Lotzová, C A Savary

Abstract

We have studied the effect of cortisone acetate (CA) on two important biological functions: (1) on NK cell-mediated cytotoxicity of B6D2F1 mice to T cell lymphoma, YAC-1 and (2) on hybrid resistance of mice to parental B6 bone marrow grafts. Results of our experiments have shown that 5 mg of CA administered i.p. was effective in significantly decreasing NK cell cytotoxic potential. The effect of CA was prompt, since a significant decrease in NK cell cytotoxicity was observed already 3 h after CA administration. This effect was, however, rather short-lasting since the NK cell cytotoxicity of CA-treated mice was comparable to that of control mice 120 h after treatment. As to the mechanism of NK cell decrease, it appears that CA affected NK cell cytotoxicity directly, since the attempts to identify suppressor cells in CA-treated mice failed. Because NK cells and bone marrow effector (BME) cells were shown to bear close resemblance, we have investigated also whether a decrease in NK cell cytotoxicity would be reflected by a decline in BME cells rejection potential. Indeed, when resistant B6D2F1 hybrid mice were pretreated with 5 mg of CA, 48 h before transplantation of 10(6) B6 parental bone marrow cells, the growth of B6 marrow ce...Continue Reading

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