PMID: 9429161Jan 16, 1998Paper

Paralysis of rat skeletal muscle equally affects contractile properties as does permanent denervation

Journal of Muscle Research and Cell Motility
M BuffelliA Cangiano

Abstract

The effects of long lasting (4-5 weeks) nerve conduction block and denervation were compared by investigating contractile, morphological and histochemical properties of slow (soleus) and fast (EDL) rat skeletal muscles. The block was based on improved perfusion techniques of the sciatic nerve with a tetrodotoxin (TTX) solution delivered at doses adequate to obtain maximal effects in the muscles. The TTX-inactivated axons retained normal histological and physiological properties such as the ability to evoke full contractile responses, to regenerate, and to completely reinnervate muscle. In spite of their intact innervation or of their full reinnervation, the TTX-paralysed muscles underwent weight loss, fibre atrophy and reduction in force, output quantitatively indistinguishable from those following denervation. The same was true for all other contractile parameters tested, that is, twitch speed, twitch to tetanus ratio, post-tetanic potentiation, endurance, and fibre type composition. The results indicate the fundamental role of activity as a regulatory signal for muscle contractile properties, while they do not support the notion of a participation of chemical, activity-independent factors in this regulation.

Citations

Jan 21, 2000·Journal of Applied Physiology·B CormeryP F Gardiner
Dec 2, 2006·Journal of Neuroscience Research·Morgana FaveroAlberto Cangiano
Jan 16, 2007·American Journal of Physiology. Cell Physiology·Z AshleyJ C Jarvis
Jun 4, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Douglas E DowJohn A Faulkner
Dec 13, 2006·Muscle & Nerve·R R RoyV R Edgerton
Oct 24, 2008·American Journal of Physiology. Cell Physiology·O AgbulutA Ferry
Apr 15, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Austin V StoneL Andrew Koman
Mar 31, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M M Shimano, J B Volpon
May 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Morgana FaveroAlberto Cangiano
Aug 20, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew G FisherJonathan C Jarvis
Jun 29, 2004·Muscle & Nerve·Douglas E DowRobert G Dennis
Nov 3, 2010·Biological Reviews of the Cambridge Philosophical Society·Kristian Gundersen
Aug 15, 2015·Annual Review of Physiology·Terje Lømo
Mar 5, 2014·Muscle & Nerve·Christopher C MatthewsPaul S Fishman
Aug 10, 2006·European Journal of Applied Physiology·Menotti Midrio

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