Paralytic and nonparalytic muscle adaptations to exercise training versus high-protein diet in individuals with long-standing spinal cord injury

Journal of Applied Physiology
Ceren Yarar-FisherMarcas M Bamman

Abstract

This study compares the effects of an 8-wk isocaloric high-protein (HP) diet versus a combination exercise (Comb-Ex) regimen on paralytic vastus lateralis (VL) and nonparalytic deltoid muscle in individuals with long-standing spinal cord injury (SCI). Fiber-type distribution, cross-sectional area (CSA), levels of translation initiation signaling proteins (Erk-1/2, Akt, p70S6K1, 4EBP1, RPS6, and FAK), and lean thigh mass were analyzed at baseline and after the 8-wk interventions. A total of 11 participants (C5-T12 levels, 21.8 ± 6.3 yr postinjury; 6 Comb-Ex and 5 HP diet) completed the study. Comb-Ex training occurred 3 days/wk and consisted of upper body resistance training (RT) in addition to neuromuscular electrical stimulation (NMES)-induced-RT for paralytic VL muscle. Strength training was combined with high-intensity arm-cranking exercises (1-min intervals at 85-90%, V̇o2peak) for improving cardiovascular endurance. For the HP diet intervention, protein and fat each comprised 30%, and carbohydrate comprised 40% of total energy. Clinical tests and muscle biopsies were performed 24 h before and after the last exercise or diet session. The Comb-Ex intervention increased Type IIa myofiber distribution and CSA in VL muscle and ...Continue Reading

References

Feb 1, 1980·European Journal of Applied Physiology and Occupational Physiology·J D MacDougallJ R Sutton
Jun 1, 1993·Journal of the Neurological Sciences·J M RoundD A Jones
Feb 1, 1993·Journal of Applied Physiology·W J RomanW J Gonyea
Sep 14, 1999·European Journal of Applied Physiology and Occupational Physiology·M J CastroG A Dudley
Sep 14, 1999·European Journal of Applied Physiology and Occupational Physiology·G A DudleyD F Apple
Oct 18, 2002·Scandinavian Journal of Medicine & Science in Sports·R M CrameriJ R Sutton
Dec 25, 2003·Muscle & Nerve·Regina M CrameriAdele Weston
Feb 24, 2004·Annual Review of Physiology·Michael J RennieFrank W Booth
May 25, 2004·Journal of Applied Physiology·Marcas M BammanRichard M Allman
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Douglas Paddon-JonesArny A Ferrando
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeong-su KimMarcas M Bamman
Aug 30, 2005·The International Journal of Biochemistry & Cell Biology·Gustavo A Nader
Nov 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jane BattJim Woodgett
Jun 7, 2008·European Journal of Applied Physiology·Louise DeldicqueMarc Francaux
Jun 21, 2008·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields
Nov 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Kirk L English, Douglas Paddon-Jones
Dec 7, 2010·Medicine and Science in Sports and Exercise·C Scott BickelMarcas M Bamman
May 31, 2013·Comprehensive Physiology·Gregory R Adams, Marcas M Bamman
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Terence E RyanKevin K McCully
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Terence E RyanKevin K McCully
Nov 23, 2013·Comprehensive Physiology·Bert BlaauwCarlo Reggiani
Jan 31, 2015·Journal of Applied Physiology·Michael PetrieRichard K Shields
Dec 23, 2015·Topics in Spinal Cord Injury Rehabilitation·C Scott BickelKevin K McCully
Jan 1, 2016·The American Journal of Clinical Nutrition·Kirk L EnglishDouglas Paddon-Jones
Mar 5, 2016·American Journal of Physiology. Endocrinology and Metabolism·Ceren Yarar-FisherMarcas M Bamman

❮ Previous
Next ❯

Citations

Mar 8, 2019·Medicine and Science in Sports and Exercise·Matthew E Holman, Ashraf S Gorgey
May 1, 2021·Frontiers in Nutrition·Joelle Leonie Flueck, Jill A Parnell

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
biopsy
biopsies

Software Mentioned

Comb
Ex
SAS
Bio
Rad Image Laboratory
ADULT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.