Paralytic shellfish toxin biosynthesis in cyanobacteria and dinoflagellates: A molecular overview

Journal of Proteomics
Da-Zhi WangLin Lin

Abstract

Paralytic shellfish toxins (PSTs) are a group of water soluble neurotoxic alkaloids produced by two different kingdoms of life, prokaryotic cyanobacteria and eukaryotic dinoflagellates. Owing to the wide distribution of these organisms, these toxic secondary metabolites account for paralytic shellfish poisonings around the world. On the other hand, their specific binding to voltage-gated sodium channels makes these toxins potentially useful in pharmacological and toxicological applications. Much effort has been devoted to the biosynthetic mechanism of PSTs, and gene clusters encoding 26 proteins involved in PST biosynthesis have been unveiled in several cyanobacterial species. Functional analysis of toxin genes indicates that PST biosynthesis in cyanobacteria is a complex process including biosynthesis, regulation, modification and export. However, less is known about the toxin biosynthesis in dinoflagellates owing to our poor understanding of the massive genome and unique chromosomal characteristics [1]. So far, few genes involved in PST biosynthesis have been identified from dinoflagellates. Moreover, the proteins involved in PST production are far from being totally explored. Thus, the origin and evolution of PST biosynthesi...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D MorseJ W Hastings
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·N A Mahmood, W W Carmichael
Jan 1, 1995·Natural Toxins·G J Doucette
Jan 1, 1996·Annual Review of Microbiology·Y Shimizu
Jul 22, 1999·Toxicon : Official Journal of the International Society on Toxinology·N LagosY Oshima
Oct 25, 2000·Trends in Plant Science·E Pichersky, D R Gang
Feb 27, 2001·Toxicon : Official Journal of the International Society on Toxinology·P VélezB A Suárez-Isla
Aug 31, 2002·Environmental Toxicology·Hans Uwe Wolf, Christian Frank
Oct 27, 2004·Toxicon : Official Journal of the International Society on Toxinology·Nadezhda V KulaginaJoseph J Pancrazio
Dec 9, 2004·Bioinformatics·Julian Gough
Mar 5, 2005·Molecular Biology and Evolution·Hwan Su YoonDebashish Bhattacharya
May 20, 2008·Applied and Environmental Microbiology·Ralf KellmannBrett A Neilan
Aug 16, 2008·Genomics·Olena Morozova, Marco A Marra
Jun 2, 2009·PloS One·Ahmed MoustafaDebashish Bhattacharya
Jun 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Julius LukesPatrick J Keeling
Aug 10, 2010·Toxicon : Official Journal of the International Society on Toxinology·Katia Soto-LiebeMónica Vásquez
Aug 18, 2010·Marine Drugs·Maria WieseBrett A Neilan
Nov 16, 2010·Molecular Biology and Evolution·Shauna A MurrayBrett A Neilan
Apr 26, 2011·Research in Microbiology·Senjie Lin
May 17, 2011·The Journal of Eukaryotic Microbiology·Stephanie A Brunelle, Frances M Van Dolah
Jun 21, 2011·Annual Review of Microbiology·Jennifer H Wisecaver, Jeremiah D Hackett
Aug 16, 2011·Applied and Environmental Microbiology·Shauna A MurrayBrett A Neilan
Nov 16, 2011·Frontiers in Pharmacology·Marijke StevensJan Tytgat
May 26, 2012·Molecular Biology and Evolution·Jeremiah D HackettDeana L Erdner
Jan 22, 2013·Applied and Environmental Microbiology·Russell J S OrrKjetill S Jakobsen
Aug 24, 2013·Marine Drugs·Russell J S OrrKjetill S Jakobsen
Oct 11, 2014·Toxicon : Official Journal of the International Society on Toxinology·Maria WieseBrett A Neilan
Aug 1, 2008·Journal of Phycology·Xavier MayaliFarooq Azam

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Citations

Jan 6, 2018·Marine Drugs·Pablo A GarcíaMaría-Ángeles Castro
Oct 3, 2017·Natural Product Reports·Roberto G S BerlinckJulie P G Rodriguez
Jan 4, 2019·Chembiochem : a European Journal of Chemical Biology·April L Lukowski, Alison R H Narayan
Feb 9, 2020·Marine Drugs·Muhamad Afiq AkbarHamidun Bunawan
Feb 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jack G Ganley, Emily R Derbyshire
Jan 27, 2019·Journal of Chemical Ecology·Zoltán TóthAttila Hettyey
Jun 20, 2019·Nature·Monica E McCallum, Emily P Balskus
Feb 20, 2020·Marine Drugs·Valeria Di DatoGiovanna Romano
Nov 25, 2018·Toxicon : Official Journal of the International Society on Toxinology·Paul M D'AgostinoSusanna A Wood
Jan 25, 2018·Journal of Natural Products·Janusz J PetkowskiSara Seager

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