Parameter identification of a dynamic model of CHO cell cultures: an experimental case study

Bioprocess and Biosystems Engineering
Ines SaraivaAnne-Lise Hantson

Abstract

In this paper, we address the problem of parameter identification in dynamic models of animal cultures, and we propose a step-by-step procedure, which gradually considers more detailed models. This procedure allows subsets of parameters to be estimated at each step, which can be used in the initialization of the next identification step. Finally, the full parameter set can be re-estimated starting from the results of the last step. The efficiency of the procedure is illustrated with a simulation case study and with the identification of a dynamic model from experimental data collected in CHO cell culture.

References

Aug 20, 1996·Journal of Biotechnology·R Pörtner, T Schäfer
Apr 5, 2001·Current Opinion in Biotechnology·L Chu, D K Robinson
Jun 2, 2005·Bioprocess and Biosystems Engineering·Ezequiel Franco-Lara, Dirk Weuster-Botz
Jun 19, 2007·Journal of Biotechnology·A GrosfilsPh Bogaerts
Aug 21, 2007·Computer Methods and Programs in Biomedicine·Giuseppina BelluLeontina D'Angiò
Oct 9, 2007·Biotechnology Advances·Era Jain, Ashok Kumar
Feb 27, 2010·Computers in Biology and Medicine·Maria Pia SaccomaniLeontina D'Angiò
Jul 27, 2010·Bioresource Technology·Francis MairetAntoine Sciandra
Nov 22, 2011·Biotechnology Journal·Woo Suk Ahn, Maciek R Antoniewicz
Aug 28, 2012·Bioprocess and Biosystems Engineering·Mihaela SbarciogAlain Vande Wouwer

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