Parameter identification of a neurological control model for the pathological head movements of cerebellar patients

Bio Systems
C F RamosJ Dee

Abstract

The objective of this research is to explore the role of the cerebellum in the human motor control system. The present study quantitatively compares the neurological control signals effecting fast, horizontal head rotations in normal subjects to those in patients with a cerebellar lesion. The method involves the use of a computer simulation model for one degree-of-freedom movements. A method for unconstrained global optimization, first proposed by Hans Bremermann (1970), is used to identify the timing and magnitudes of the input neurological control signals to the model, which are compared to recorded electromyograms (EMGs). Experimentally recorded kinematics from cerebellar patients and from normal subjects were used to drive the parameter search. These simulations found that cerebellar patients' neurological control signals were altered with respect to those of normal subjects, and suggest that the electromyographic activity of cerebellar patients may comprise at least five bursts of activity whereas normal subjects typically exhibit only three. The results are discussed with respect to the hypothesis that the cerebellum may be involved in both the timing and magnitudes of the neurological control signals effecting voluntary ...Continue Reading

References

Nov 1, 1992·Journal of Biomedical Engineering·W H ZangemeisterS Lehman
Jan 1, 1990·Biological cybernetics·C F Ramos, L W Stark
Jan 1, 1990·Medical & Biological Engineering & Computing·C F RamosL W Stark
Dec 1, 1985·Experimental Neurology·B Hannaford, L Stark
Jan 1, 1981·Biological cybernetics·W H ZangemeisterL Stark
Jan 1, 1981·Biological cybernetics·W H ZangemeisterL Stark
Sep 1, 1984·Journal of Motor Behavior·B HannafordM Nam
May 13, 1983·Science·S KirkpatrickM P Vecchi
Mar 1, 1987·Journal of Motor Behavior·C F Ramos, L W Stark

❮ Previous
Next ❯

Citations

Nov 1, 1995·Journal of the Neurological Sciences·W H ZangemeisterV Hoemberg
Apr 30, 1998·Journal of the Neurological Sciences·J Dee, W H Zangemeister

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the New York Academy of Sciences
W H Zangemeister, L Stark
Journal of Neurology, Neurosurgery, and Psychiatry
M HallettR R Young
Journal of the Neurological Sciences
W H ZangemeisterT Waite
© 2022 Meta ULC. All rights reserved