Parameter sensitivity analysis of IL-6 signalling pathways

IET Systems Biology
Y ChuJuergen Hahn

Abstract

Signal transduction pathways generally consist of a large number of individual components and have an even greater number of parameters describing their reaction kinetics. Although the structure of some signalling pathways can be found in the literature, many of the parameters are not well known and they would need to be re-estimated from experimental data for each specific case. However it is not feasible to estimate hundreds of parameters because of the cost of the experiments associated with generating data. Parameter sensitivity analysis can address this situation as it investigates how the system behaviour is changed by variations of parameters and the analysis identifies which parameters play a key role in signal transduction. Only these important parameters need then be re-estimated using data from further experiments. This article presents a detailed parameter sensitivity analysis of the JAK/STAT and MAPK signal transduction pathway that is used for signalling by the cytokine IL-6. As no parameter sensitivity analysis technique is known to work best for all situations, a comparison of the results returned by four techniques is presented: differential analysis, the Morris method, a sampling-based approach and the Fourier...Continue Reading

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Citations

Jan 26, 2011·IET Systems Biology·C MoyaJ Hahn
Jul 24, 2012·Circulation Research·Stephen Y Chan, Joseph Loscalzo
Mar 17, 2011·BMC Systems Biology·Thanneer M Perumal, Rudiyanto Gunawan
Feb 23, 2010·Journal of Theoretical Biology·Roland KaunasJuergen Hahn
Aug 8, 2009·Journal of Theoretical Biology·Thanneer M PerumalRudiyanto Gunawan
Jun 24, 2009·Statistics in Medicine·Alison McArdleJuergen Hahn
Jul 19, 2015·Cytokine & Growth Factor Reviews·Anna DittrichFred Schaper
May 10, 2013·ACS Synthetic Biology·Nikolaos AnesiadisRadhakrishnan Mahadevan

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