Parameterising User Uptake in Economic Evaluations: The role of discrete choice experiments

Health Economics
Fern Terris-PrestholtPeter Vickerman

Abstract

Model-based economic evaluations of new interventions have shown that user behaviour (uptake) is a critical driver of overall impact achieved. However, early economic evaluations, prior to introduction, often rely on assumed levels of uptake based on expert opinion or uptake of similar interventions. In addition to the likely uncertainty surrounding these uptake assumptions, they also do not allow for uptake to be a function of product, intervention, or user characteristics. This letter proposes using uptake projections from discrete choice experiments (DCE) to better parameterize uptake and substitution in cost-effectiveness models. A simple impact model is developed and illustrated using an example from the HIV prevention field in South Africa. Comparison between the conventional approach and the DCE-based approach shows that, in our example, DCE-based impact predictions varied by up to 50% from conventional estimates and provided far more nuanced projections. In the absence of observed uptake data and to model the effect of variations in intervention characteristics, DCE-based uptake predictions are likely to greatly improve models parameterizing uptake solely based on expert opinion. This is particularly important for globa...Continue Reading

References

May 1, 1997·Social Science & Medicine·S D Pinkerton, P R Abramson
Nov 7, 1998·The Journal of the Association of Nurses in AIDS Care : JANAC·S D PinkertonM E Turk
Nov 17, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Esther W de Bekker-GrobEwout W Steyerberg
Jun 5, 2010·Sexually Transmitted Infections·S Verguet, J A Walsh
Jun 10, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brian G WilliamsEleanor Gouws
Aug 16, 2011·Journal of Theoretical Biology·Dobromir T DimitrovBenoit Masse
Apr 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rochelle P WalenskyA David Paltiel
Aug 6, 2013·Sexually Transmitted Infections·Stéphane VerguetJulia A Walsh
Jun 13, 2014·PharmacoEconomics·Emily Lancsar, Joffre Swait
Jul 22, 2014·JAMA : the Journal of the American Medical Association·Harsha ThirumurthyKawango Agot
Jan 27, 2015·The Patient·Benjamin H SalampessyMattijs S Lambooij

❮ Previous
Next ❯

Citations

May 4, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Ariel Beresniak, Danielle Dupont
Dec 22, 2016·The Lancet Infectious Diseases·Matthew QuaifePeter Vickerman
Mar 15, 2018·Journal of the International AIDS Society·Matthew QuaifePeter Vickerman
Jan 31, 2018·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Matthew QuaifePeter Vickerman
Apr 18, 2019·BMC Pregnancy and Childbirth·Caroline M VassKatherine Payne
Mar 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michelle VogelzangMatthew Quaife
Mar 6, 2019·Trials·Fern Terris-PrestholtUNKNOWN VMMC study team

❮ Previous
Next ❯

Methods Mentioned

BETA
circumcision

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.