Parameters influencing augmentation of cerebral blood flow by cervical spinal cord stimulation

Acta neurochirurgica
J ZhongOren Sagher

Abstract

Cervical spinal cord stimulation (SCS) has been shown to augment cerebral blood flow (CBF) and protect the brain from focal ischemia. However, the application of SCS in the treatment of cerebral ischemia requires a better understanding of the limits of the cerebrovascular effect and the optimal stimulation parameters. In the present study, we investigated the effects of various stimulation parameters on CBF augmentation, as well as the issue of tachyphylaxis of the CBF response. SCS was performed in adult Sprague Dawley rats, and CBF was assessed using cortical laser Doppler flowmetry (LDF). In separate experimental series, stimulation amplitude, frequency, and pulse width were varied, and the effect on the LDF response was recorded. Finally, using the stimulation parameters found to elicit the strongest LDF response, we examined the effect of lengthening the period of SCS. SCS elicited a robust increase in cortical LDF values as previously demonstrated. The magnitude of the response varied in a dose-dependent fashion with the stimulation amplitude. LDF values increased by more than 80% over baseline with an amplitude of 1.5 mA. The optimal pulse width and frequency of the stimulation were 0.25 ms and 50 Hz, respectively. Lengt...Continue Reading

Citations

Feb 16, 2016·Neurosurgical Review·Ming-Xing LiuShi-Ting Li
Dec 18, 2007·Autonomic Neuroscience : Basic & Clinical·Mingyuan WuRobert D Foreman
Jun 6, 2012·Neurological Research·Qiu-Meng ZhouShi-Ting Li
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Jan 19, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Huixian LiWeiping Cheng
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Jun 5, 2021·Brain Circulation·Zhen-Jie Wang, Takao Yasuhara
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